CAJ | 학술논문

目的：观察不同检测时段的瞬时弹性成像（FS）下肝硬度值变化。方法收集4731例次慢性肝病FS肝纤维化检测结果，比较每日9个不同时段肝硬度值的差异。以肝硬度值为因变量，以检测时段、性别、是否住院患者等3个因素为主效应因素，年龄为协变量进行协方差分析。结果4731例次平均肝硬度值为（8.8±8.3） kPa。不同时段肝硬度值比较总体差异有统计学意义（P＜0.05），每日10、11、9、8、7时段肝硬度值接近，低于17、16、14、15时段肝硬度值（P均＜0.05）。不同时段中性别、年龄分布、住院患者比例比较差异均有统计学意义（P＜0.01或0.006）。检测时段、性别、是否住院患者、年龄对肝硬度值均存在单独的影响（P＜0.01）；在不同的检测时段和性别和（或）是否住院的组合对肝硬度值还存在附加影响（P＜0.01）。结论检测的时段可能影响肝硬度值，FS检测应固定于上午一个时段内进行。
목적：관찰불동검측시단적순시탄성성상（FS）하간경도치변화。방법수집4731례차만성간병FS간섬유화검측결과，비교매일9개불동시단간경도치적차이。이간경도치위인변량，이검측시단、성별、시부주원환자등3개인소위주효응인소，년령위협변량진행협방차분석。결과4731례차평균간경도치위（8.8±8.3） kPa。불동시단간경도치비교총체차이유통계학의의（P＜0.05），매일10、11、9、8、7시단간경도치접근，저우17、16、14、15시단간경도치（P균＜0.05）。불동시단중성별、년령분포、주원환자비례비교차이균유통계학의의（P＜0.01혹0.006）。검측시단、성별、시부주원환자、년령대간경도치균존재단독적영향（P＜0.01）；재불동적검측시단화성별화（혹）시부주원적조합대간경도치환존재부가영향（P＜0.01）。결론검측적시단가능영향간경도치，FS검측응고정우상오일개시단내진행。
Objective To observe the changes in the liver stiffness (LS)measured by fibroscan (FS)at different time points. Methods Transient elastography results of 4731 cases with chronic hepatopathy were retrospectively analyzed and the discrepancy among the values measured at nine time points was statistical-ly compared. LS was regarded as the dependent variable,detection time point,gender,and hospitalization or not as main effect factors and age as the covariate. Univariate analysis of covariance was performed. Results Mean LS level of all 4731 subjects was (8.8 ±8.3)kPa. The LS measured at different time points significantly differed (P<0.05). LS levels detected at 10,11,9,8 and 7 a.m. were almost similar,whereas signifi-cantly lower than those measured at 17,16,14 and 15 p.m. (all P<0.05). Gender,age and the proportion of hospitalized patients significantly differed among different time points (P<0.01 or 0.006). Detection time point,gender,hospitalization or not,and age are independent factors affecting LS levels (all P<0.01 ).These three factors equally exert a combined effect upon LS levels (P<0.01). Conclusion Detection time point probably affects the measurement of LS. Therefore,the measurement of LS should be conducted at a fixed period in the morning.