CAJ | 학술논문

目的：研究N-末端脑钠肽前体（NT-proBNP）、D-二聚体浓度对老年社区获得性肺炎（CAP）的严重程度评估和结果预测。方法对180例老年CAP患者评估临床变量和肺炎严重指数（PSI），同时检测患者D-二聚体和NT-proBNP。按照PSI 评分分组，比较各组NT-proBNP、D-二聚体的浓度，评价这些指标与CAP严重程度的关系。结果各组NT-proBNP、D-二聚体随着老年CAP严重程度升高而升高（P＜0.01）。与PSI评分组合，NT-proBNP浓度随着病情严重程度的升高而升高。结论 NT-proBNP、D-二聚体可作为老年CAP患者严重程度分层较为有效的标志物。
목적：연구N-말단뇌납태전체（NT-proBNP）、D-이취체농도대노년사구획득성폐염（CAP）적엄중정도평고화결과예측。방법대180례노년CAP환자평고림상변량화폐염엄중지수（PSI），동시검측환자D-이취체화NT-proBNP。안조PSI 평분분조，비교각조NT-proBNP、D-이취체적농도，평개저사지표여CAP엄중정도적관계。결과각조NT-proBNP、D-이취체수착노년CAP엄중정도승고이승고（P＜0.01）。여PSI평분조합，NT-proBNP농도수착병정엄중정도적승고이승고。결론 NT-proBNP、D-이취체가작위노년CAP환자엄중정도분층교위유효적표지물。
Objective To evaluate the prediction and evaluation of N-terminal pro brain natriuretic peptide (NT-proBNP)and D-Dimer levels upon the severity of community-acquired pneumonia (CAP)in se-nile individuals. Methods Clinical variables and pneumonia severity index (PSI)of 180 elderly patients with CAP were evaluated and NT-proBNP and D-Dimer levels were measured simultaneously. All patients were di-vided into different groups according to PSI score. The levels of NT-proBNP and D-Dimer were statistically compared among all groups to evaluate the relationship between these indexes and the severity of CAP. Results NT-proBNP and D-Dimer levels were significantly increased with the severity of CAP in each group (P<0.01 ). Combined with PSI,the level of NT-proBNP was elevated over the severity of this disease. Conclusion NT-proBNP and D-Dimer can be used as effective markers for stratification of the severity of CAP in elderly patients.