CAJ | 학술논문

目的：观察妥洛特罗贴剂治疗急性呼吸道感染患儿夜间咳嗽的临床疗效和安全性。方法将113例具有夜间咳嗽症状的急性支气管（肺）炎患儿按就诊先后随机分为观察组（57例）和对照组（56例），观察组在综合治疗的基础上加用妥洛特罗贴剂，对照组在综合治疗基础上加服用丙卡特罗片剂，疗程均为5 d，比较两组患儿夜间咳嗽评分、夜间睡眠评分、总有效率及不良反应。结果治疗5 d 后，观察组夜间咳嗽、夜间睡眠评分均低于对照组（0.78±0.41 vs.1.09±0.39；0.72±0.49 vs.1.05±0.40，P均＜0.05）。观察组总有效率（82％）显著高于对照组（64％）（P＜0.05）。观察组2例（4％）发生局部皮肤发红瘙痒，反应轻微，对照组6例（11％）发生不良反应，包括4例手颤和2例心悸。结论妥洛特罗贴剂治疗急性呼吸道感染患儿夜间咳嗽疗效显著，可明显缓解夜间咳嗽症状和改善夜间睡眠质量，且不良反应少。
목적：관찰타락특라첩제치료급성호흡도감염환인야간해수적림상료효화안전성。방법장113례구유야간해수증상적급성지기관（폐）염환인안취진선후수궤분위관찰조（57례）화대조조（56례），관찰조재종합치료적기출상가용타락특라첩제，대조조재종합치료기출상가복용병잡특라편제，료정균위5 d，비교량조환인야간해수평분、야간수면평분、총유효솔급불량반응。결과치료5 d 후，관찰조야간해수、야간수면평분균저우대조조（0.78±0.41 vs.1.09±0.39；0.72±0.49 vs.1.05±0.40，P균＜0.05）。관찰조총유효솔（82％）현저고우대조조（64％）（P＜0.05）。관찰조2례（4％）발생국부피부발홍소양，반응경미，대조조6례（11％）발생불량반응，포괄4례수전화2례심계。결론타락특라첩제치료급성호흡도감염환인야간해수료효현저，가명현완해야간해수증상화개선야간수면질량，차불량반응소。
Objective To observe the clinical efficacy and safety of tulobuterol patches in treatment of nighttime cough in children with acute respiratory tract infection. Methods One hundred and thirteen chil-dren with acute respiratory tract infection and nighttime cough were randomly divided into observation (n=57) and control groups (n=56). Besides comprehensive treatment,tulobuterol patches were supplemented in the observation group and procaterol hydrochloride tablet in the control group. The course of treatment was 5 days.Symptom scores of nighttime cough,nocturnal sleep,total effective rate and adverse reactions were statistically compared between two groups. Results After 5 day-therapy,symptom scores of nighttime cough and nocturnal sleep in the observation group were significantly lower than those in the control group (0.78 ±0.41 vs. 1.09 ± 0.39;0.72 ±0.49 vs. 1.05 ±0.40,P<0.05). Total effective rate was 82%in the observation group,signif-icantly higher compared with 64% in the control group (P<0.05 ). In the observation group,localized skin redness and itching occurred in two patients (4%). In the control group,adverse reactions including hand tremors and heart palpitations were observed in 6 patients (1 1%). Conclusions Tulobuterol patches exert a high efficacy in treatment of nighttime cough in children with acute respiratory tract infection,which significant-ly alleviates the symptoms,improves sleep quality and yields few adverse reactions.