CAJ | 학술논문

【目的】探讨分析冠状动脉粥样硬化性心脏病（CHD）患者血清胱抑素C（CysC）、CA125和骨保护素（OPG）的水平变化及临床意义。【方法】选取本院158例经冠状动脉造影确诊的 CHD 患者作为观察组（CHD组），另选95例健康人作为健康对照组。分别应用免疫比浊法、化学免疫发光法和ELISA法比较不同组别和不同病变支数患者的CysC、CA125、OPG 水平。【结果】与健康对照组比较，CHD组CysC、CA125、OPG水平明显升高（ P ＜0．05或 P ＜0．01）；单支、双支、多支病变组3组血清CysC、CA125、OPG 水平逐渐升高，左室射血分数（LVEF）逐渐下降，且差异均有显著性（ P ＜0．05或 P ＜0．01）；NYHAⅠ级、Ⅱ级、Ⅲ级、Ⅳ级组血清CysC、CA125、OPG水平逐渐升高，LVEF逐渐下降，且差异均有显著性（ P＜0．05或 P＜0．01）。CysC、CA125、OPG 水平均与冠脉病变支数、心功能级别呈正相关（ P ＜0．01），与 LVEF呈负相关（ P ＜0．01）。【结论】联合检测血浆CysC、BMG、OPG 水平不仅能评价心功能受损程度，而且有助于早期发现CHD和有助于冠脉病变严重程度的判断及预后判断。
【목적】탐토분석관상동맥죽양경화성심장병（CHD）환자혈청광억소C（CysC）、CA125화골보호소（OPG）적수평변화급림상의의。【방법】선취본원158례경관상동맥조영학진적 CHD 환자작위관찰조（CHD조），령선95례건강인작위건강대조조。분별응용면역비탁법、화학면역발광법화ELISA법비교불동조별화불동병변지수환자적CysC、CA125、OPG 수평。【결과】여건강대조조비교，CHD조CysC、CA125、OPG수평명현승고（ P ＜0．05혹 P ＜0．01）；단지、쌍지、다지병변조3조혈청CysC、CA125、OPG 수평축점승고，좌실사혈분수（LVEF）축점하강，차차이균유현저성（ P ＜0．05혹 P ＜0．01）；NYHAⅠ급、Ⅱ급、Ⅲ급、Ⅳ급조혈청CysC、CA125、OPG수평축점승고，LVEF축점하강，차차이균유현저성（ P＜0．05혹 P＜0．01）。CysC、CA125、OPG 수평균여관맥병변지수、심공능급별정정상관（ P ＜0．01），여 LVEF정부상관（ P ＜0．01）。【결론】연합검측혈장CysC、BMG、OPG 수평불부능평개심공능수손정도，이차유조우조기발현CHD화유조우관맥병변엄중정도적판단급예후판단。
Objective To explore the changes of serum levels of cystain C (CysC) ,CA125 and osteoprote-gerin(OPG) in patients with coronary heart disease(CHD) and their clinical significance .[Methods]A total of 158 CHD patients in our hospital were chosen as experimental group .Other 95 healthy subjects were chosen as healthy control group .Serum levels of CysC ,CA125 and OPG were compared among different groups and dis-eased vessels by using immunoturbidimetry ,chemiluminescence immunoassay and ELISA .[Results] Com-pared with healthy control group ,serum levels of CysC ,CA125 and OPG in CHD group were obviously in-creased( P <0 .05 or P<0 .01) .Serum levels of CysC ,CA125 and OPG in single ,double and multiple vessel disease groups were gradually increased ,while left ventricular ejection fraction (LVEF) was gradually de-creased ,and there was significant difference( P<0 .05 or P<0 .01) .Serum levels of CysC ,CA125 and OPG level in NYHA Ⅰ ,Ⅱ ,Ⅲ and Ⅳ groups were gradually increased ,but LVEF was gradually decreased ,and there was significant difference( P <0 .05 or P <0 .01) .Serum levels of CysC ,CA125 and OPG were posi-tively correlated with the number of coronary disease vessels and cardiac function classification ( P <0 .01) , and negatively correlated with LVEF ( P <0 .01) .[Conclusion] Serum levels of CysC ,CA125 and OPG can not only evaluate the degree of cardiac function impairment ,but also is helpful for early diagnosis of CHD ,as-sessment of the severity of coronary artery disease and prognosis .