医学临床研究
醫學臨床研究
의학림상연구
JOURNAL OF CLINICAL RESEARCH
2014年
7期
1265-1266
,共2页
手足口病/血液%白细胞介素6/血液%肿瘤坏死因子α/血液%利钠肽 ,脑/血液
手足口病/血液%白細胞介素6/血液%腫瘤壞死因子α/血液%利鈉肽 ,腦/血液
수족구병/혈액%백세포개소6/혈액%종류배사인자α/혈액%리납태 ,뇌/혈액
Hand,Foot and Mouth Disease/blood%Interleukin-6/blood%Tumor Necrosis Factor-alpha/blood%Na-triuretic Peptide,Brain/blood
【目的】探讨手足口病不同临床分期(1、2、3、4期)肿瘤坏死因子(tumor necrosis factor ,TNF)、白介素-6(IL-6)及B型脑钠肽(BNP)的变化特点,为临床评估此类患者提供参考。【方法】选择2011年5月至2013年10月在本院就诊的手足口病患儿292例(其中1期156例,2期106例,3期20例,4期10例),于患儿入院24 h内抽血行TNF、IL-6、BNP检测。观察比较不同分期手足口病患儿细胞因子及BNP的变化特点。【结果】各期TNF、IL-6、BNP水平均较健康对照组明显增高,2期、3期患儿TNF、IL-6、BNP水平明显高于1期,4期的TNF、IL-6、BNP水平明显高于2期、3期水平,且差异相比较均有显著性( P <0.05)。2、3期TNF、IL-6、BNP水平相比较差异无显著性( P >0.05)。【结论】随着患儿病情加重,TNF、IL-6及BNP水平随之相应增高,T N F、IL-6及BN P水平可用于手足口病患儿病情评估的参考指标。
【目的】探討手足口病不同臨床分期(1、2、3、4期)腫瘤壞死因子(tumor necrosis factor ,TNF)、白介素-6(IL-6)及B型腦鈉肽(BNP)的變化特點,為臨床評估此類患者提供參攷。【方法】選擇2011年5月至2013年10月在本院就診的手足口病患兒292例(其中1期156例,2期106例,3期20例,4期10例),于患兒入院24 h內抽血行TNF、IL-6、BNP檢測。觀察比較不同分期手足口病患兒細胞因子及BNP的變化特點。【結果】各期TNF、IL-6、BNP水平均較健康對照組明顯增高,2期、3期患兒TNF、IL-6、BNP水平明顯高于1期,4期的TNF、IL-6、BNP水平明顯高于2期、3期水平,且差異相比較均有顯著性( P <0.05)。2、3期TNF、IL-6、BNP水平相比較差異無顯著性( P >0.05)。【結論】隨著患兒病情加重,TNF、IL-6及BNP水平隨之相應增高,T N F、IL-6及BN P水平可用于手足口病患兒病情評估的參攷指標。
【목적】탐토수족구병불동림상분기(1、2、3、4기)종류배사인자(tumor necrosis factor ,TNF)、백개소-6(IL-6)급B형뇌납태(BNP)적변화특점,위림상평고차류환자제공삼고。【방법】선택2011년5월지2013년10월재본원취진적수족구병환인292례(기중1기156례,2기106례,3기20례,4기10례),우환인입원24 h내추혈행TNF、IL-6、BNP검측。관찰비교불동분기수족구병환인세포인자급BNP적변화특점。【결과】각기TNF、IL-6、BNP수평균교건강대조조명현증고,2기、3기환인TNF、IL-6、BNP수평명현고우1기,4기적TNF、IL-6、BNP수평명현고우2기、3기수평,차차이상비교균유현저성( P <0.05)。2、3기TNF、IL-6、BNP수평상비교차이무현저성( P >0.05)。【결론】수착환인병정가중,TNF、IL-6급BNP수평수지상응증고,T N F、IL-6급BN P수평가용우수족구병환인병정평고적삼고지표。
Objective To explore the changes of cytokines tumor necrosis factor (TNF) ,interleukin-6(IL-6) and B-type natriuret-ic peptide BNP in children with different stages of hand ,foot and mouth disease in order to provide the reference for clinical evaluation of the patients .[Methods]Totally 292 patients with different stages of hand ,foot and mouth disease in our hospital from May 2011 to Oct .2013 were chosen .There were 156 children in stage 1 ,and 106 children in stage 2 ,and 20 children in stage 3 and 10 children in stage 4 .Blood was drawn within 24h after admission .TNF ,IL-6 and BNP were determined .The changes of cytokines and BNP in children with different stages of hand ,foot and mouth disease were observed and compared .[Results]Compared with healthy control group ,the levels of TNF ,IL-6 and BNP in different stage were increased obviously .The levels of TNF ,IL-6 and BNP of patients in stage 2 and stage 3 were obviously higher than those in stage 1 ,and those in stage 4 were obviously higher than those in stage 2 and stage 3 ,and there was significant difference ( P<0 .05) .There was no significant difference in the levels of TNF ,IL-6 and BNP be-tween stage 2 and stage 3( P>0 .05) .[Conclusion]The levels of TNF ,IL-6 and BNP increase with the severity of pediatric patients . The levels of TNF ,IL-6 and BNP can be used as the reference indexes for evaluating the condition of patients with hand ,foot and mouth disease .