CAJ | 학술논문

化疗是肿瘤治疗的重要手段之一，其严重的副作用影响其在临床上的广泛应用。同时，肿瘤细胞的耐药现象也是化疗失败的主要原因之一。因此，开发新型抗肿瘤药物是当前研究热点之一。抗菌肽是先天免疫系统的重要组分，部分抗菌肽表现出高选择性的抗肿瘤活性，并且其特殊的作用机制避免肿瘤细胞耐药的发生。因此，抗菌肽可作为一类新型抗肿瘤药物。
화료시종류치료적중요수단지일，기엄중적부작용영향기재림상상적엄범응용。동시，종류세포적내약현상야시화료실패적주요원인지일。인차，개발신형항종류약물시당전연구열점지일。항균태시선천면역계통적중요조분，부분항균태표현출고선택성적항종류활성，병차기특수적작용궤제피면종류세포내약적발생。인차，항균태가작위일류신형항종류약물。
Chemotherapy is a major strategy for cancer therapy;however ,the severe side effects restrain its clini-cal application.Meanwhile , drug resistance of tumor cells is another reason for the failure of cancer chemotherapy.Therefore,the development of novel antitumor agents become the focus of the recent antitumor re-search.Antimicrobial peptides are significant components in innate immune system , some of them present selective antitumor activity,and the unique mechanism of action circumvent the drug resistance of tumor cells.Thus,antimicro-bial peptides might be promising candidates for cancer therapy.