CAJ | 학술논문

目的：优化黄芩苷滴丸制备工艺，考察药物体外释放度。方法以聚乙二醇6000（PEG 6000）-共聚维酮（PVP S630）为基质制备黄芩苷滴丸，以圆整度和重量差异为评价指标，通过正交试验优化制备工艺。结果最佳处方和制备工艺条件为：黄芩苷、PEG 6000、PVP S630质量比为1∶9∶1，滴制时药料温度80～90℃，滴距6cm，滴速30滴/min，二甲基硅油为冷却剂，冷却温度为10～15℃。制备的滴丸在40min的平均溶出度为86.54％。结论优选的黄芩苷滴丸制备工艺合理可行，能增加药物的溶出度。
목적：우화황금감적환제비공예，고찰약물체외석방도。방법이취을이순6000（PEG 6000）-공취유동（PVP S630）위기질제비황금감적환，이원정도화중량차이위평개지표，통과정교시험우화제비공예。결과최가처방화제비공예조건위：황금감、PEG 6000、PVP S630질량비위1∶9∶1，적제시약료온도80～90℃，적거6cm，적속30적/min，이갑기규유위냉각제，냉각온도위10～15℃。제비적적환재40min적평균용출도위86.54％。결론우선적황금감적환제비공예합리가행，능증가약물적용출도。
OBJECTIVE To investigate optimal preparation technology of Baicalin Dropping Pills and study its dissolution in vitro.METHODS The baicalin dropping pills were prepared with PEG 6000 and PVP S630 as ma-trix.Orthogonal design was conducted to explore the influencing factors of baicalin dropping pills by evaluating the in -dexes of roundness and weight difference.RESULTS The optimal technology conditions were as follows:the ratio of baicalin,PEG 6000 and PVP S630 as 1∶9∶1,temperature of dropping drug liquid 80~90℃,dropping distance 6cm, dropping speed 30d· min -1 ,dimethy-silicone oil as cooling agent and the cooling temperature was 10~15℃.The average dissolution amount of Baicalin from Dropping Pills was 86.54%at 40 min.CONCLUSION The optimized process of Baicalin Dropping Pills is reasonable and feasible ,which has a good effect on increasing the drug dissolu-tion.