中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2014年
24期
39-42
,共4页
婴儿,早产%呼吸暂停%经鼻间歇正压通气%经鼻持续气道正压通气%临床分析
嬰兒,早產%呼吸暫停%經鼻間歇正壓通氣%經鼻持續氣道正壓通氣%臨床分析
영인,조산%호흡잠정%경비간헐정압통기%경비지속기도정압통기%림상분석
Premature birth%Apnea%Nasal intermittent positive pressure ventilationt%Nasal continuous positive airway pressure%Clinical analysis
目的 比较经鼻间歇正压通气(NIPPV)与经鼻持续气道正压通气(NCPAP)治疗早产儿原发性呼吸暂停(AOP)的疗效,为AOP的治疗提供科学依据.方法 选择76例AOP患儿,按随机数字表法分为NIPPV组(40例)和NCPAP组(36例).比较两组血气变化、治疗的疗效、两组治疗后需有创机械通气的比率(即为治疗无效率)、辅助通气时间、并发症发生情况及预后.结果 两组治疗前的血气分析比较差异无统计学意义(P＞0.05),治疗后1,12h血气分析比较差异有统计学意义(P＜ 0.05).NIPPV组治愈率、有效率、无效率均明显优于NCPAP组,辅助通气时间明显短于NCPAP组,差异有统计学意义(P＜0.05).NIPPV组治愈率、有效率、无效率均明显优于NCPAP组[82.5％(33/40)比61.1％(22/36)、92.5％(37/40)比80.6％(29/36)、7.5％(3/40)比19.4％(7/36)],辅助通气时间明显短于NCPAP组[(39.45±6.99)h比(69.39±20.51)h],差异有统计学意义(P＜0.05).两组脑室内出血、支气管肺发育不良、新生儿坏死性小肠结肠炎发生率比较差异无统计学意义(P＞0.05).NIPPV组早产儿视网膜病、脑室周围脑白质软化发生率明显低于NCPAP组[2.5％(1/40)比13.9％(5/36)、2.5％(1/40)比11.1％(4/36)],差异有统计学意义(P＜0.05).结论 NIPPV治疗早产儿反复呼吸暂停疗效及预后优于NCPAP.
目的 比較經鼻間歇正壓通氣(NIPPV)與經鼻持續氣道正壓通氣(NCPAP)治療早產兒原髮性呼吸暫停(AOP)的療效,為AOP的治療提供科學依據.方法 選擇76例AOP患兒,按隨機數字錶法分為NIPPV組(40例)和NCPAP組(36例).比較兩組血氣變化、治療的療效、兩組治療後需有創機械通氣的比率(即為治療無效率)、輔助通氣時間、併髮癥髮生情況及預後.結果 兩組治療前的血氣分析比較差異無統計學意義(P＞0.05),治療後1,12h血氣分析比較差異有統計學意義(P＜ 0.05).NIPPV組治愈率、有效率、無效率均明顯優于NCPAP組,輔助通氣時間明顯短于NCPAP組,差異有統計學意義(P＜0.05).NIPPV組治愈率、有效率、無效率均明顯優于NCPAP組[82.5％(33/40)比61.1％(22/36)、92.5％(37/40)比80.6％(29/36)、7.5％(3/40)比19.4％(7/36)],輔助通氣時間明顯短于NCPAP組[(39.45±6.99)h比(69.39±20.51)h],差異有統計學意義(P＜0.05).兩組腦室內齣血、支氣管肺髮育不良、新生兒壞死性小腸結腸炎髮生率比較差異無統計學意義(P＞0.05).NIPPV組早產兒視網膜病、腦室週圍腦白質軟化髮生率明顯低于NCPAP組[2.5％(1/40)比13.9％(5/36)、2.5％(1/40)比11.1％(4/36)],差異有統計學意義(P＜0.05).結論 NIPPV治療早產兒反複呼吸暫停療效及預後優于NCPAP.
목적 비교경비간헐정압통기(NIPPV)여경비지속기도정압통기(NCPAP)치료조산인원발성호흡잠정(AOP)적료효,위AOP적치료제공과학의거.방법 선택76례AOP환인,안수궤수자표법분위NIPPV조(40례)화NCPAP조(36례).비교량조혈기변화、치료적료효、량조치료후수유창궤계통기적비솔(즉위치료무효솔)、보조통기시간、병발증발생정황급예후.결과 량조치료전적혈기분석비교차이무통계학의의(P＞0.05),치료후1,12h혈기분석비교차이유통계학의의(P＜ 0.05).NIPPV조치유솔、유효솔、무효솔균명현우우NCPAP조,보조통기시간명현단우NCPAP조,차이유통계학의의(P＜0.05).NIPPV조치유솔、유효솔、무효솔균명현우우NCPAP조[82.5％(33/40)비61.1％(22/36)、92.5％(37/40)비80.6％(29/36)、7.5％(3/40)비19.4％(7/36)],보조통기시간명현단우NCPAP조[(39.45±6.99)h비(69.39±20.51)h],차이유통계학의의(P＜0.05).량조뇌실내출혈、지기관폐발육불량、신생인배사성소장결장염발생솔비교차이무통계학의의(P＞0.05).NIPPV조조산인시망막병、뇌실주위뇌백질연화발생솔명현저우NCPAP조[2.5％(1/40)비13.9％(5/36)、2.5％(1/40)비11.1％(4/36)],차이유통계학의의(P＜0.05).결론 NIPPV치료조산인반복호흡잠정료효급예후우우NCPAP.
Objective To compare nasal intermittent positive pressure ventilation （NIPPV） with nasal continuous positive airway pressure (NCPAP) treatment of primary apenea of premature (AOP) effect,and provide a scientific basis for the AOP treatment.Methods Seventy-six cases of children with AOP were randomly divided into NIPPV group (40 cases) and NCPAP group (36 cases).Comparison of two groups changes of blood gas,curative effect,after treatment for invasive mechanical ventilation ratio,ventilation time,and so on.Results Blood gas analysis of two groups before treatment had no significant difference (P ＞ 0.05),1,12 h after treatment of blood gas analysis was statistically significant (P ＜ 0.05).The cure rate,effective rate and inefficiency in NIPPV group were significantly better than those in NCPAP group [82.5％ (33/40)vs.61.1％ (22/36),92.5％ (37/40) vs.80.6％ (29/36),7.5％ (3/40) vs.19.4％ (7/36)].Assisted ventilation time was significantly shorter in NCPAP group[(39.45 ± 6.99) h vs.(69.39 ± 20.51) h].The difference was statistically significant (P ＜ 0.05).Two groups of intraventricular hemorrhage,bronchial pulmonary hypoplasia,neonatal necrotizing enterocolitis incidence rate had no significant difference (P ＞0.05).In NIPPV group the incidence rate of premature infant retina disease and cererbral white matter softening around the ventricle was significantly lower than that in NCPAP group [2.5％ (1/40) vs.13.9％(5/36),2.5％(1/40) vs.11.1％(4/36)].The difference was statistically significant (P ＜ 0.05).Conclusion NIPPV in the treatment of recurrent apnea in premature infants curative effect and prognosis is better than NCPAP.
