中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2012年
23期
3527-3528
,共2页
妊娠期高血压疾病%肿瘤坏死因子α%白细胞介素6%基质金属蛋白酶9
妊娠期高血壓疾病%腫瘤壞死因子α%白細胞介素6%基質金屬蛋白酶9
임신기고혈압질병%종류배사인자α%백세포개소6%기질금속단백매9
Hypertensive disorder complicating pregnancy%Tumor necrosis factor alpha%Interleukin 6%Matrix metalloproteinase 9
目的 探讨肿瘤坏死因子α(TNF-α)、白细胞介素6(IL-6)和基质金属蛋白酶9(MMP-9)在妊娠期高血压疾病(HDCP)发病机制中的作用.方法 选择妊娠期高血压疾病患者(观察组)50例,采用酶联免疫吸附(ELISA)法检测血清TNF-α、IL-6和MMP-9水平,并以20例正常妊娠孕妇(对照组)作为对照.结果 观察组患者血清TNF-α、IL-6水平分别为(29.9±4.6)ng/L、(32.6±5.4)ng/L,均明显高于对照组的(8.3±1.5)ng/L、(9.8±1.8)ng/L(t=4.16、4.38,均P＜0.05);观察组患者血清MMP-9水平为(31.1±4.9)mg/L,显著低于对照组的(117.9±14.1)mg/L(t=3.89,P＜0.05).MMP-9与TNF-α、IL-6呈负相关(r=-0.372、-0.328,均P＜0.05).结论 HDCP患者TNF-α和IL-6水平升高,MMP-9表达水平下降,TNF-α、IL-6和MMP-9在HDCP的发病机制中可能起着重要作用.
目的 探討腫瘤壞死因子α(TNF-α)、白細胞介素6(IL-6)和基質金屬蛋白酶9(MMP-9)在妊娠期高血壓疾病(HDCP)髮病機製中的作用.方法 選擇妊娠期高血壓疾病患者(觀察組)50例,採用酶聯免疫吸附(ELISA)法檢測血清TNF-α、IL-6和MMP-9水平,併以20例正常妊娠孕婦(對照組)作為對照.結果 觀察組患者血清TNF-α、IL-6水平分彆為(29.9±4.6)ng/L、(32.6±5.4)ng/L,均明顯高于對照組的(8.3±1.5)ng/L、(9.8±1.8)ng/L(t=4.16、4.38,均P＜0.05);觀察組患者血清MMP-9水平為(31.1±4.9)mg/L,顯著低于對照組的(117.9±14.1)mg/L(t=3.89,P＜0.05).MMP-9與TNF-α、IL-6呈負相關(r=-0.372、-0.328,均P＜0.05).結論 HDCP患者TNF-α和IL-6水平升高,MMP-9錶達水平下降,TNF-α、IL-6和MMP-9在HDCP的髮病機製中可能起著重要作用.
목적 탐토종류배사인자α(TNF-α)、백세포개소6(IL-6)화기질금속단백매9(MMP-9)재임신기고혈압질병(HDCP)발병궤제중적작용.방법 선택임신기고혈압질병환자(관찰조)50례,채용매련면역흡부(ELISA)법검측혈청TNF-α、IL-6화MMP-9수평,병이20례정상임신잉부(대조조)작위대조.결과 관찰조환자혈청TNF-α、IL-6수평분별위(29.9±4.6)ng/L、(32.6±5.4)ng/L,균명현고우대조조적(8.3±1.5)ng/L、(9.8±1.8)ng/L(t=4.16、4.38,균P＜0.05);관찰조환자혈청MMP-9수평위(31.1±4.9)mg/L,현저저우대조조적(117.9±14.1)mg/L(t=3.89,P＜0.05).MMP-9여TNF-α、IL-6정부상관(r=-0.372、-0.328,균P＜0.05).결론 HDCP환자TNF-α화IL-6수평승고,MMP-9표체수평하강,TNF-α、IL-6화MMP-9재HDCP적발병궤제중가능기착중요작용.
Objective To explore the effect of the serum tumor necrosis factor alpha(TNF-α),interleukin 6(IL-6)and matrix metalloproteinase 9(MMP-9)in the pathogenesis of hypertensive disorder complicating pregnancy(HDCP).Methods The serum levels of TNF-α,IL-6 and MMP-9 in 50 patients with HDCP and 20 normal pregnant women were detected by ELISA.Results The serum levels of TNF-α and IL-6 in HDCP group were higher than the control group(t=4.16,4.38,all P＜0.05).The serum level of MMP-9 in HDCP group was lower than the control group(t=3.89,P＜0.05).Negative correlation was observed between TNF-α,IL-6 and MMP-9 in HDCP group(r=-0.372,-0.328,all P＜0.05).Conclusion The serum levels of TNF-α and IL-6 increased significantly,while the serum level of MMP-9 decreased.TNF-α,IL-6 and MMP-9 may play important roles in pathogenesis and development of HDCP.
