中国中医药信息杂志
中國中醫藥信息雜誌
중국중의약신식잡지
CHINESE JOURNAL OF INFORMATION ON TRADITIONAL CHINESE MEDICINE
2014年
8期
46-48
,共3页
邓桂球%张蓓%张喆%陈飞燕%劳梓钊%李耿%吴庆光%程宏辉
鄧桂毬%張蓓%張喆%陳飛燕%勞梓釗%李耿%吳慶光%程宏輝
산계구%장배%장철%진비연%로재쇠%리경%오경광%정굉휘
六味顺激胶囊%肠易激综合征%内脏敏感性%五羟色胺%大鼠
六味順激膠囊%腸易激綜閤徵%內髒敏感性%五羥色胺%大鼠
륙미순격효낭%장역격종합정%내장민감성%오간색알%대서
Liuwei Shunji Capsule%irritable bowel syndrome%visceral hypersensitivity%5-HT%rats
目的:观察六味顺激胶囊对肝郁脾虚型肠易激综合征(IBS)大鼠的生存状态、内脏敏感性、五羟色胺(5-HT)水平的影响,探讨其作用机制。方法 SD大鼠随机分为正常组、模型组、阳性药组和六味顺激胶囊高、中、低剂量组,采用番泻叶结合束缚的方法复制肝郁脾虚型IBS大鼠模型,造模后第2日,各给药组给予相应药物,每日1次,连续2周。观察肝郁脾虚型IBS大鼠生存状态、内脏敏感性,测定血清及下丘脑5-HT含量。结果与模型组比较,六味顺激胶囊高、中、低剂量组大鼠体质量增加(P<0.05),泄泻、神态倦怠、皮毛散乱、脾气暴躁、易怒等症状改善,内脏敏感性显著降低(P<0.01),血清及下丘脑5-HT含量显著降低(P<0.01)。结论六味顺激胶囊能显著改善肝郁脾虚型IBS模型大鼠的生存状态及肠道功能紊乱状态,其可通过调节大鼠5-HT水平发挥治疗作用。
目的:觀察六味順激膠囊對肝鬱脾虛型腸易激綜閤徵(IBS)大鼠的生存狀態、內髒敏感性、五羥色胺(5-HT)水平的影響,探討其作用機製。方法 SD大鼠隨機分為正常組、模型組、暘性藥組和六味順激膠囊高、中、低劑量組,採用番瀉葉結閤束縳的方法複製肝鬱脾虛型IBS大鼠模型,造模後第2日,各給藥組給予相應藥物,每日1次,連續2週。觀察肝鬱脾虛型IBS大鼠生存狀態、內髒敏感性,測定血清及下丘腦5-HT含量。結果與模型組比較,六味順激膠囊高、中、低劑量組大鼠體質量增加(P<0.05),洩瀉、神態倦怠、皮毛散亂、脾氣暴躁、易怒等癥狀改善,內髒敏感性顯著降低(P<0.01),血清及下丘腦5-HT含量顯著降低(P<0.01)。結論六味順激膠囊能顯著改善肝鬱脾虛型IBS模型大鼠的生存狀態及腸道功能紊亂狀態,其可通過調節大鼠5-HT水平髮揮治療作用。
목적:관찰륙미순격효낭대간욱비허형장역격종합정(IBS)대서적생존상태、내장민감성、오간색알(5-HT)수평적영향,탐토기작용궤제。방법 SD대서수궤분위정상조、모형조、양성약조화륙미순격효낭고、중、저제량조,채용번사협결합속박적방법복제간욱비허형IBS대서모형,조모후제2일,각급약조급여상응약물,매일1차,련속2주。관찰간욱비허형IBS대서생존상태、내장민감성,측정혈청급하구뇌5-HT함량。결과여모형조비교,륙미순격효낭고、중、저제량조대서체질량증가(P<0.05),설사、신태권태、피모산란、비기폭조、역노등증상개선,내장민감성현저강저(P<0.01),혈청급하구뇌5-HT함량현저강저(P<0.01)。결론륙미순격효낭능현저개선간욱비허형IBS모형대서적생존상태급장도공능문란상태,기가통과조절대서5-HT수평발휘치료작용。
Objective To observe the therapeutic effects of Liuwei Shunji Capsule on survival state, visceral hypersensitivity, the content of 5-HT of model rats with liver depression and spleen deficiency-type irritable bowel syndrome (IBS), and explore its mechanism.Methods SD rats were randomly divided into normal group, model group, pinaverium bromide group and Liuwei Shunji Capsule of high, medium and low dose groups. Senna with restraint stress was used in duplicating liver depression and spleen deficiency-type IBS model. From the second day after the model was established, each drug treatment group was administered with corresponding drugs once a day for two weeks. The effects of Liuwei Shunji Capsule on survival state, visceral hypersensitivity, the content of 5-HT in serum and hypothalamus were observed.Results Compared with model group, Liuwei Shunji Capsule could raise weight growth rate of model rats with liver depression and spleen deficiency-type IBS (P<0.05), improve their diarrhea, fatigue demeanor, fur quality, irritability and other symptoms, significantly decrease their visceral hypersensitivity, the content of 5-HT in serum and hypothalamus (P<0.01).Conclusion Liuwei Shunji Capsule can effectively improve survival state and intestinal disorders of rats with liver depression and spleen deficiency-type IBS, and the mechanism of treatment could be realized through regulating 5-HT level.