CAJ | 학술논문

目的：探讨中药复方治疗非酒精性脂肪肝的用药规律。方法检索中国期刊全文数据库(1979年1月-2014年1月)、中文科技期刊数据库(1989年1月-2014年1月)和中国生物医学文献数据库(1979年1月-2014年1月)公开发表文献中治疗非酒精性脂肪肝的中药复方，建立相应数据库，采用频次分析、聚类分析和关联规则分析方法对中药复方进行数据挖掘。结果共获得治疗非酒精性脂肪肝的中药复方107个，涉及药物179种、频次1499次；以使用频次≥10次的37种作为主要药物进行聚类分析，归为活血药、清热药、利湿药、补气药、消积药、化痰药、补阴药、行气药和泻下9大类；经关联规则分析，共得有趣关联规则33条，药对30对。结论数据挖掘有助于解读中药复方治疗非酒精性脂肪肝的用药规律。
목적：탐토중약복방치료비주정성지방간적용약규률。방법검색중국기간전문수거고(1979년1월-2014년1월)、중문과기기간수거고(1989년1월-2014년1월)화중국생물의학문헌수거고(1979년1월-2014년1월)공개발표문헌중치료비주정성지방간적중약복방，건립상응수거고，채용빈차분석、취류분석화관련규칙분석방법대중약복방진행수거알굴。결과공획득치료비주정성지방간적중약복방107개，섭급약물179충、빈차1499차；이사용빈차≥10차적37충작위주요약물진행취류분석，귀위활혈약、청열약、리습약、보기약、소적약、화담약、보음약、행기약화사하9대류；경관련규칙분석，공득유취관련규칙33조，약대30대。결론수거알굴유조우해독중약복방치료비주정성지방간적용약규률。
Objective To explore the regularities and rules of compound herbal formulae for nonalcoholic fatty liver disease (NAFLD).Methods Compound herbal formulae on NAFLD published in journals of CNKI (1979.1-2014.1), VIP (1989.1-2014.1) and CBMdisc (1979.1-2014.1) were analyzed with association rule, frequency analysis and cluster analysis.Results In 107 prescriptions, 179 herbs were involved, and frequency of usage of those herbs was 1499. A cluster analysis was used to analyze 37 herbs with high frequency (≥10) of usage, which were classified into 9 clusters including promoting circulation, clearing heat herb, diuretic herb, food stagnation herb, regulating qi herb, phlegm-resolving herb, qi tonics herb, yin-nourishing herb, qi-activating herb and purgating herb. 30 pairs of herbs and 33 rules for NAFLD were obtained by association rule analysis.Conclusion It was a point of view to understand the regularities and rules of Chinese herb prescription on NAFLD by data mining.