CAJ | 학술논문

目的探讨霍奇金淋巴瘤(HL)复发、难治的相关因素,分析复发、难治性HL患者的生存情况.方法对62例HL患者的临床资料进行回顾性分析,对其临床特征、治疗方法等与复发、难治的关系进行相关性分析.结果 62例HL患者中,12例(19.35％)为复发、难治性.病理类型(P=0.026)、淋巴结区≥3个(P=0.030)和大包块(P=0.006)与复发、难治有关.复发、难治性HL患者中位生存时间为69.5个月(27 ～129个月),复发、难治性HL及其他HL患者的5年总生存(OS)率分别为66.7％和88.8％,二组差异无统计学意义(P=0.117),无事件生存(EFS)率分别为52.4％和87.9％,差异有统计学意义(P=0.006).结论 HL的病理类型、淋巴结区≥3个和大包块与复发、难治关系密切,同时,短期(＜1年)内复发是复发、难治性HL患者的不良预后因素,值得关注.
목적 탐토곽기금림파류(HL)복발、난치적상관인소,분석복발、난치성HL환자적생존정황.방법 대62례HL환자적림상자료진행회고성분석,대기림상특정、치료방법등여복발、난치적관계진행상관성분석.결과 62례HL환자중,12례(19.35％)위복발、난치성.병리류형(P=0.026)、림파결구≥3개(P=0.030)화대포괴(P=0.006)여복발、난치유관.복발、난치성HL환자중위생존시간위69.5개월(27 ～129개월),복발、난치성HL급기타HL환자적5년총생존(OS)솔분별위66.7％화88.8％,이조차이무통계학의의(P=0.117),무사건생존(EFS)솔분별위52.4％화87.9％,차이유통계학의의(P=0.006).결론 HL적병리류형、림파결구≥3개화대포괴여복발、난치관계밀절,동시,단기(＜1년)내복발시복발、난치성HL환자적불량예후인소,치득관주.
Objective To investigate the related factors of relapsed refractory Hodgkin lymphoma (HL),analysis treatment and adverse reactions.Methods Clinical features and treatment outcome of 62 HL patients were analyzed retrospectively.Results Of the 62 HL patients,12 patients(19.35 ％) were relapsed refractory HL.Pathologic type (P =0.026),lymph node area ≥ 3 (P =0.030) and large mass (P =0.006) were important factors for relapsed and refractory.The median overall survival time of relapsed refractory HL was 69.5 months (27-129 months).The 5 year overall survival (OS) rates in relapsed refractory HL and others were 66.7 ％ and 88.8 ％ respectively (P =0.117).The 5 year event-free survival (EFS) rates in relapsed refractory HL were 52.4 ％ and others 87.9 ％ respectively (P =0.006).Conclusion Pathologic type,lymph node area ≥3 and large mass are closely related with refractory refractory.HL.At the same time,recurrence in the short-term (＜ 1 year) is the independent prognostic factor for patients with relapsed refractory HL.