疑难病杂志
疑難病雜誌
의난병잡지
JOURNAL OF DIFFICULT AND COMPLICATED CASES
2014年
8期
800-803,806
,共5页
卓安山%李奕%官振标%曾葭%李雷%赵红霞
卓安山%李奕%官振標%曾葭%李雷%趙紅霞
탁안산%리혁%관진표%증가%리뢰%조홍하
慢性阻塞性肺疾病%急性加重期%肺性脑病%无创正压通气%纳洛酮
慢性阻塞性肺疾病%急性加重期%肺性腦病%無創正壓通氣%納洛酮
만성조새성폐질병%급성가중기%폐성뇌병%무창정압통기%납락동
Chronic obstructive pulmonary disease%Acute exacerbation%Pulmonary encephalopathy%Noninvasive positive pressure ventilation%Naloxone
目的:观察无创正压通气( NPPV)联合纳洛酮治疗慢性阻塞性肺疾病急性发作( AECOPD )合并肺性脑病的疗效。方法将AECOPD合并肺性脑病的患者78例随机分成2组,观察组39例,在综合治疗的基础上,采用NPPV联合纳洛酮治疗;对照组39例,除不用纳洛酮外,其他治疗同观察组。观察2组抢救成功率和失败率,并比较治疗前及治疗后3 d呼吸频率( RR)、心率( HR)、指脉氧饱和度( SpO2)、呼气末二氧化碳分压( PET CO2)及动脉血气指标的变化。结果(1)观察组总抢救成功率(92?.3%)虽较对照组(84.6%)高,但2组比较差异无统计学意义( P >0.05);(2)与治疗前比较,2组治疗3 d后RR、HR均改善( P <0.01),2组治疗后比较差异无统计学意义( P >0.05)。呼吸困难程度评分治疗前与治疗后比较:观察组[(1.70±0.61)分 vs.(2.78±0.64)分]、对照组[(1.72±0.58)分vs.(2.44±0.33)分]均改善明显( P <0.05),2组治疗后比较差异有统计学意义( P <0.05)。(3)与治疗前比较,治疗3 d后观察组pH、SaO2、PaO2、PaCO2、SpO2、PET CO2均改善,对照组除SpO2外,其余指标亦改善( P <0.05或P <0.01)。2组pH、PaCO2、PETCO2比较差异有统计学意义( P <0.01)。结论 NPPV治疗AECOPD合并肺性脑病具有较好的疗效,及早联用呼吸兴奋剂纳洛酮,可提高治疗效果,提高抢救成功率,降低气管插管率和病死率。
目的:觀察無創正壓通氣( NPPV)聯閤納洛酮治療慢性阻塞性肺疾病急性髮作( AECOPD )閤併肺性腦病的療效。方法將AECOPD閤併肺性腦病的患者78例隨機分成2組,觀察組39例,在綜閤治療的基礎上,採用NPPV聯閤納洛酮治療;對照組39例,除不用納洛酮外,其他治療同觀察組。觀察2組搶救成功率和失敗率,併比較治療前及治療後3 d呼吸頻率( RR)、心率( HR)、指脈氧飽和度( SpO2)、呼氣末二氧化碳分壓( PET CO2)及動脈血氣指標的變化。結果(1)觀察組總搶救成功率(92?.3%)雖較對照組(84.6%)高,但2組比較差異無統計學意義( P >0.05);(2)與治療前比較,2組治療3 d後RR、HR均改善( P <0.01),2組治療後比較差異無統計學意義( P >0.05)。呼吸睏難程度評分治療前與治療後比較:觀察組[(1.70±0.61)分 vs.(2.78±0.64)分]、對照組[(1.72±0.58)分vs.(2.44±0.33)分]均改善明顯( P <0.05),2組治療後比較差異有統計學意義( P <0.05)。(3)與治療前比較,治療3 d後觀察組pH、SaO2、PaO2、PaCO2、SpO2、PET CO2均改善,對照組除SpO2外,其餘指標亦改善( P <0.05或P <0.01)。2組pH、PaCO2、PETCO2比較差異有統計學意義( P <0.01)。結論 NPPV治療AECOPD閤併肺性腦病具有較好的療效,及早聯用呼吸興奮劑納洛酮,可提高治療效果,提高搶救成功率,降低氣管插管率和病死率。
목적:관찰무창정압통기( NPPV)연합납락동치료만성조새성폐질병급성발작( AECOPD )합병폐성뇌병적료효。방법장AECOPD합병폐성뇌병적환자78례수궤분성2조,관찰조39례,재종합치료적기출상,채용NPPV연합납락동치료;대조조39례,제불용납락동외,기타치료동관찰조。관찰2조창구성공솔화실패솔,병비교치료전급치료후3 d호흡빈솔( RR)、심솔( HR)、지맥양포화도( SpO2)、호기말이양화탄분압( PET CO2)급동맥혈기지표적변화。결과(1)관찰조총창구성공솔(92?.3%)수교대조조(84.6%)고,단2조비교차이무통계학의의( P >0.05);(2)여치료전비교,2조치료3 d후RR、HR균개선( P <0.01),2조치료후비교차이무통계학의의( P >0.05)。호흡곤난정도평분치료전여치료후비교:관찰조[(1.70±0.61)분 vs.(2.78±0.64)분]、대조조[(1.72±0.58)분vs.(2.44±0.33)분]균개선명현( P <0.05),2조치료후비교차이유통계학의의( P <0.05)。(3)여치료전비교,치료3 d후관찰조pH、SaO2、PaO2、PaCO2、SpO2、PET CO2균개선,대조조제SpO2외,기여지표역개선( P <0.05혹P <0.01)。2조pH、PaCO2、PETCO2비교차이유통계학의의( P <0.01)。결론 NPPV치료AECOPD합병폐성뇌병구유교호적료효,급조련용호흡흥강제납락동,가제고치료효과,제고창구성공솔,강저기관삽관솔화병사솔。
Objective To observe the therapeutic effect of noninvasive positive pressure ventilation ( NPPV) com-bined with naloxone in treatment of acute exacerbation of chronic obstructive pulmonary disease ( AECOPD) complicated with pulmonary encephalopathy .Methods Seventy-eight cases of AECOPD patients with pulmonary encephalopathy were randomly divided into 2 groups, 39 cases in observation group , on the basis of comprehensive therapy , using NPPV combined with nal-oxone in treatment;39 cases in the control group , without naloxone , other treatment was same as the observation group .The 2 groups were observed the success rate and failure rate , and 3 d respiratory frequency ( RR) , heart rate ( HR) , pulse oxygen saturation (SpO2), end tidal carbon dioxide partial pressure (PETCO2) and changes of arterial blood gas indexes were com-pared before and after treatment .Results (1) Observation group's total success rate (92.3%) is higher than the control group (84.6%), but no significant differences between the 2 groups were found ( P >0.05); (2) Compared with before treatment, after 3 day treatment, RR and HR were improved in both of the 2 groups ( P <0.01), no significant difference were found between the 2 groups ( P >0.05).Comparison of respiratory score of before treatment and after treatment , both of the observation group [(1.70 ±0.61) vs.(2.78 ±0.64)] and the control group [(1.72 ±0.58) vs.(2.44 ± 0.33)] were improved significantly ( P <0.05), after treatment, there were significant difference between the 2 groups (P <0.05).(3) Compared with before treatment, after 3 days treatment, observation group's pH, SaO2, PaO2, PaCO2, SpO2, PETCO2 group were improved; in the control group, except SpO2,other indicators also improved (P <0.05, P <0.01).pH、PaCO2、PETCO2 were significant differences between the 2 groups( P <0.01).Conclusion The NPPV in treat-ment of AECOPD with pulmonary encephalopathy has good effect;early naloxone combined with respiratory stimulant can sig-nificantly improve the therapeutic effect ,improve the success rate ,and reduce the rate of endotracheal intubation and mortality .