疑难病杂志
疑難病雜誌
의난병잡지
JOURNAL OF DIFFICULT AND COMPLICATED CASES
2014年
8期
793-795
,共3页
脑梗死,急性%胱抑素C%同型半胱氨酸%颈动脉粥样硬化
腦梗死,急性%胱抑素C%同型半胱氨痠%頸動脈粥樣硬化
뇌경사,급성%광억소C%동형반광안산%경동맥죽양경화
Cerebral infarction,acute%Cystatin C%Homocysteine%Carotid atherosclerosis
目的:探讨急性脑梗死( ACI)患者血清胱抑素C ( Cys C)水平与血同型半胱氨酸( Hcy)以及颈动脉粥样硬化( CAA)的相关性。方法选择120例脑梗死患者为观察组,同期住院非脑血管疾病患者60例为对照组。检测并比较2组血清Cys C、三酰甘油(TG)、胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、空腹血糖( FPG)、Hcy水平,以及应用彩色多普勒超声检测其颈动脉内膜中层厚度( IMT)。结果观察组和对照组血清Cys C水平分别为(1後.36±0.24) mg/L和(1.03±0.13) mg/L,2组比较差异有统计学意义( P <0.01);2组TG、TC、LDL-C、HDL-C、FPG、Hcy水平及颈动脉IMT比较差异亦均有统计学意义( P <0.01)。血清Cys C水平与TC、TG、HDL-C、LDL-C、FPG均无相关性( r =0.076、-0.158、-0.040、0.012、-0.176, P均>0.05),而与血Hcy及颈动脉IMT均呈显著正相关( r =0.871、0.819, P均<0.01)。结论高Cys C血症是脑梗死重要危险因素,与血Hcy呈正相关,且与颈动脉粥样硬化的形成密切相关。
目的:探討急性腦梗死( ACI)患者血清胱抑素C ( Cys C)水平與血同型半胱氨痠( Hcy)以及頸動脈粥樣硬化( CAA)的相關性。方法選擇120例腦梗死患者為觀察組,同期住院非腦血管疾病患者60例為對照組。檢測併比較2組血清Cys C、三酰甘油(TG)、膽固醇(TC)、低密度脂蛋白膽固醇(LDL-C)、高密度脂蛋白膽固醇(HDL-C)、空腹血糖( FPG)、Hcy水平,以及應用綵色多普勒超聲檢測其頸動脈內膜中層厚度( IMT)。結果觀察組和對照組血清Cys C水平分彆為(1後.36±0.24) mg/L和(1.03±0.13) mg/L,2組比較差異有統計學意義( P <0.01);2組TG、TC、LDL-C、HDL-C、FPG、Hcy水平及頸動脈IMT比較差異亦均有統計學意義( P <0.01)。血清Cys C水平與TC、TG、HDL-C、LDL-C、FPG均無相關性( r =0.076、-0.158、-0.040、0.012、-0.176, P均>0.05),而與血Hcy及頸動脈IMT均呈顯著正相關( r =0.871、0.819, P均<0.01)。結論高Cys C血癥是腦梗死重要危險因素,與血Hcy呈正相關,且與頸動脈粥樣硬化的形成密切相關。
목적:탐토급성뇌경사( ACI)환자혈청광억소C ( Cys C)수평여혈동형반광안산( Hcy)이급경동맥죽양경화( CAA)적상관성。방법선택120례뇌경사환자위관찰조,동기주원비뇌혈관질병환자60례위대조조。검측병비교2조혈청Cys C、삼선감유(TG)、담고순(TC)、저밀도지단백담고순(LDL-C)、고밀도지단백담고순(HDL-C)、공복혈당( FPG)、Hcy수평,이급응용채색다보륵초성검측기경동맥내막중층후도( IMT)。결과관찰조화대조조혈청Cys C수평분별위(1후.36±0.24) mg/L화(1.03±0.13) mg/L,2조비교차이유통계학의의( P <0.01);2조TG、TC、LDL-C、HDL-C、FPG、Hcy수평급경동맥IMT비교차이역균유통계학의의( P <0.01)。혈청Cys C수평여TC、TG、HDL-C、LDL-C、FPG균무상관성( r =0.076、-0.158、-0.040、0.012、-0.176, P균>0.05),이여혈Hcy급경동맥IMT균정현저정상관( r =0.871、0.819, P균<0.01)。결론고Cys C혈증시뇌경사중요위험인소,여혈Hcy정정상관,차여경동맥죽양경화적형성밀절상관。
Objective To investigate the correlation of serum cystatin C ( Cys-C) , the level of plasma homocysteine (Hcy) and carotid atherosclerosis (CAA) in acute cerebral infarction (ACI) patients'.Methods One hundred and twenty cases of cerebral infarction patients were enrolled as observation group , in the same period , 60 cases of non-cerebrovascular disease patients were enrolled as a control group .The serum Cys-C, three glycerol ( TG) , cholesterol ( TC) , low density lipo-protein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), fasting blood glucose (FPG), Hcy levels of the 2 groups were detected and compared , as well as used the color Doppler ultrasound to detect the carotid artery intima-media thick-ness (IMT).Results The observation group and the control group of serum Cys-C were (1.36 ±0.24) mg/L and (1.03 ± 0.13) mg/L, there was significant difference between the 2 groups ( P <0.01);TG, TC, LDL-C, HDL-C, FPG, Hcy level and carotid artery IMT were significant different between the 2 groups ( P <0.01).Serum Cys-C level and TC, TG, HDL-C, LDL-C, FPG are not correlated ( r =0.076, -0.158, -0.040, 0.012, -0.176, P >0.05) and blood Hcy and carotid artery IMT were significantly positive correlated ( r =0.871, 0.819, P <0.01).Conclusion High Cys-C level is an impor-tant risk factor of ACI , and was positively correlated with serum Hcy , and closely related to the formation of CAA .