疑难病杂志
疑難病雜誌
의난병잡지
JOURNAL OF DIFFICULT AND COMPLICATED CASES
2014年
8期
790-792
,共3页
心肌梗死,急性%生长分化因子-15%肌酸激酶同工酶%肌钙蛋白I%肌红蛋白%相关分析
心肌梗死,急性%生長分化因子-15%肌痠激酶同工酶%肌鈣蛋白I%肌紅蛋白%相關分析
심기경사,급성%생장분화인자-15%기산격매동공매%기개단백I%기홍단백%상관분석
Myocardial infarction,acute%Growth differentiation factor-15%Creatine kinase isoenzyme%Troponin I%Myoglobin%Correlation analysis
目的：研究急性心肌梗死（AMI）患者血浆生长分化因子-15（GDF-15）、心肌梗死三项[肌酸激酶同工酶（CK-MB）、肌钙蛋白I（cTnI）、肌红蛋白（Mb）]表达水平及其之间的关系。方法以116例AMI患者作为AMI组，分为2个亚组，其中ST段抬高型心肌梗死（ STEMI亚组）58例，非ST段抬高型心肌梗死（ NSTEMI亚组）58例，采用酶联免疫吸附试验（ ELISA法）测定血GDF-15水平，采用荧光免疫定量法测定CK-MB、cTnI、Mb水平；并以106例健康查体者作为健康对照组进行比较。结果 AMI组血GDF-15、CK-MB、cTnI、Mb水平较健康对照组均显著增高（ P ＜0构．01），其中STEMI亚组较NSTEMI亚组升高更明显（ P ＜0．05）。相关分析显示GDF-15与CK-MB、cTnI、Mb均呈正相关（ r ＝0．558、r ＝0．579、r ＝0．545， P ＜0．01）。结论在AMI发病过程中，血GDF-15、CK-MB、cTnI、Mb水平升高，且STEMI患者升高更明显。 GDF-15与CK-MB、cTnI、Mb呈正相关，联合检测可能更有助于AMI的早期诊断和危险分层。
目的：研究急性心肌梗死（AMI）患者血漿生長分化因子-15（GDF-15）、心肌梗死三項[肌痠激酶同工酶（CK-MB）、肌鈣蛋白I（cTnI）、肌紅蛋白（Mb）]錶達水平及其之間的關繫。方法以116例AMI患者作為AMI組，分為2箇亞組，其中ST段抬高型心肌梗死（ STEMI亞組）58例，非ST段抬高型心肌梗死（ NSTEMI亞組）58例，採用酶聯免疫吸附試驗（ ELISA法）測定血GDF-15水平，採用熒光免疫定量法測定CK-MB、cTnI、Mb水平；併以106例健康查體者作為健康對照組進行比較。結果 AMI組血GDF-15、CK-MB、cTnI、Mb水平較健康對照組均顯著增高（ P ＜0構．01），其中STEMI亞組較NSTEMI亞組升高更明顯（ P ＜0．05）。相關分析顯示GDF-15與CK-MB、cTnI、Mb均呈正相關（ r ＝0．558、r ＝0．579、r ＝0．545， P ＜0．01）。結論在AMI髮病過程中，血GDF-15、CK-MB、cTnI、Mb水平升高，且STEMI患者升高更明顯。 GDF-15與CK-MB、cTnI、Mb呈正相關，聯閤檢測可能更有助于AMI的早期診斷和危險分層。
목적：연구급성심기경사（AMI）환자혈장생장분화인자-15（GDF-15）、심기경사삼항[기산격매동공매（CK-MB）、기개단백I（cTnI）、기홍단백（Mb）]표체수평급기지간적관계。방법이116례AMI환자작위AMI조，분위2개아조，기중ST단태고형심기경사（ STEMI아조）58례，비ST단태고형심기경사（ NSTEMI아조）58례，채용매련면역흡부시험（ ELISA법）측정혈GDF-15수평，채용형광면역정량법측정CK-MB、cTnI、Mb수평；병이106례건강사체자작위건강대조조진행비교。결과 AMI조혈GDF-15、CK-MB、cTnI、Mb수평교건강대조조균현저증고（ P ＜0구．01），기중STEMI아조교NSTEMI아조승고경명현（ P ＜0．05）。상관분석현시GDF-15여CK-MB、cTnI、Mb균정정상관（ r ＝0．558、r ＝0．579、r ＝0．545， P ＜0．01）。결론재AMI발병과정중，혈GDF-15、CK-MB、cTnI、Mb수평승고，차STEMI환자승고경명현。 GDF-15여CK-MB、cTnI、Mb정정상관，연합검측가능경유조우AMI적조기진단화위험분층。
Objective To investigate the relationship between acute myocardial infarction ( AMI ) patients serum growth differentiation factor-15 (GDF-15), the myocardial infarction three [isoenzyme of creatine kinase (CK-MB), troponin I (cTnI), myoglobin (Mb)] expression.Methods 116 cases of AMI patients as AMI group, they were divided into 2 sub-groups, the ST segment elevation myocardial infarction (STEMI group) with 58 cases, non ST segment elevation myocardial infarction (NSTEMI) group with 58 cases, using enzyme-linked immunosorbent assay (ELISA method) to determine the ser-um GDF-15 level, CK-MB, cTnI, Mb levels were determined using fluorescence immunoassay method;and 106 healthy sub-jects as healthy controls were compared .Results AMI group's GDF-15, CK-MB, cTnI, Mb levels were increased than health-y control group significantly ( P <0.01), where STEMI sub group were increased obviously than in NSTEMI group ( P <0.05).Correlation analysis showed that GDF-15 and CK-MB, cTnI, Mb were positively correlated ( r =0.558, r =0.579, r =0.545, P <0.01).Conclusion In the pathogenesis of AMI, blood GDF-15, CK-MB, cTnI, Mb, and STEMI were in-creased obviously .GDF-15 and CK-MB, cTnI, Mb were positively correlated , the combined detection of these indexes is helpful for early diagnosis and risk stratification of AMI .
