CAJ | 학술논문

目的：探讨熊去氧胆酸联合复方甘草酸苷片治疗乙型病毒性肝炎（乙肝）肝硬化伴胆汁淤积的疗效。方法将乙肝肝硬化伴胆汁淤积患者79例随机分为治疗组40例与对照组39例，治疗组予熊去氧胆酸联合复方甘草酸苷片治疗，对照组单用熊去氧胆酸治疗，疗程4周，比较两组患者血清总胆汁酸、ALT、总胆红素与直接胆红素（DB）、碱性磷酸酶（ALP）、γ-谷氨酰转肽酶（γ-GGT）水平，并进行瘙痒评分及观察不良反应的发生情况。结果治疗后两组患者瘙痒评分、总胆汁酸、ALT、总胆红素、DB、γ-GGT水平均较治疗前明显下降（P＜0.01），且观察组治疗后瘙痒评分、总胆汁酸、ALT、γ-GGT的改善均优于对照组（P＜0.05）。结论熊去氧胆酸和复方甘草酸苷片联合治疗可提高乙肝肝硬化伴胆汁淤积的疗效。
목적：탐토웅거양담산연합복방감초산감편치료을형병독성간염（을간）간경화반담즙어적적료효。방법장을간간경화반담즙어적환자79례수궤분위치료조40례여대조조39례，치료조여웅거양담산연합복방감초산감편치료，대조조단용웅거양담산치료，료정4주，비교량조환자혈청총담즙산、ALT、총담홍소여직접담홍소（DB）、감성린산매（ALP）、γ-곡안선전태매（γ-GGT）수평，병진행소양평분급관찰불량반응적발생정황。결과치료후량조환자소양평분、총담즙산、ALT、총담홍소、DB、γ-GGT수평균교치료전명현하강（P＜0.01），차관찰조치료후소양평분、총담즙산、ALT、γ-GGT적개선균우우대조조（P＜0.05）。결론웅거양담산화복방감초산감편연합치료가제고을간간경화반담즙어적적료효。
Objective Toinvestigatetheclinicalefficacyofursodeoxycholicacidcombinedwithgly-cyrrhizintabletsintreatmentofhepatitisBcirrhosiscomplicatedwithcholestasis.Methods Atotalof79pa-tients suffering from hepatitis B cirrhosis complicated with cholestasis were randomly divided into the treatment (n=40)and control groups (n=39). In the treatment group,patients received combined therapy of glycyr-rhizin tablets and ursodeoxycholic acid. Those in the control group were treated with ursodeoxycholic acid a-lone. The course of treatment in both groups was four weeks. The serum total bile acid (TBA),alanine amin-otransferase (ALT),total bilirubin (TB),direct bilirubin (DB),alkaline phosphatase enzyme (ALP),γ-glutamyl endopeptidase (γ-GGT)level and the incidence of pruritus scores and adverse reactions were statisti-callycomparedbetweentwogroups.Results Afterrespectivetreatment,pruritusscore,TBA,ALT,TB, DB,γ-GGT levels in patients from both groups were significantly decreased compared with those levels before treatment (all P<0 01 ). In addition,pruritus score,TBA,ALT and γ-GGT in the treatment group signifi-cantlydifferedfromthoseinthecontrolgroup(allP<0.05).Conclusion Ursodeoxycholicacidincombina-tion with glycyrrhizin tablets therapy could improve the clinical efficacy in treatment of hepatitis B cirrhosis complicated with cholestasis.