实用心脑肺血管病杂志
實用心腦肺血管病雜誌
실용심뇌폐혈관병잡지
PRACTICAL JOURNAL OF CARDIAC CEREBRAL PNEUMAL AND VASCULAR DISEASE
2014年
8期
9-11
,共3页
陈文忠%赖艳娴%周劲东%刘凯
陳文忠%賴豔嫻%週勁東%劉凱
진문충%뢰염한%주경동%류개
主动脉疾病%动脉瘤,夹层%基质金属蛋白酶9%诊断%预后
主動脈疾病%動脈瘤,夾層%基質金屬蛋白酶9%診斷%預後
주동맥질병%동맥류,협층%기질금속단백매9%진단%예후
Aortic disease%Aneurysm,dissecting%Matrix metalloproteinase 9%Diagnosis%Prognosis
目的：探讨血清基质金属蛋白酶9（MMP-9）水平对早期主动脉夹层（AD）的诊断价值及预后评估作用。方法选择2011年1月-2014年1月在广州市第一人民医院心内科及广州市南沙中心医院心内科住院的AD患者60例，根据主动脉计算机断层扫描血管造影（ CTA）结果分为Stanford A型32例（ A组）和Stanford B型28例（ B组）；另选取同期在我院体检健康者30例作为对照组。采用酶联免疫吸附法（ ELISA）检测3组受试者血清MMP-9水平。结果 A组患者血清MMP-9水平为（56.31±10.36）μg/L，B组为（45.73±9.57）μg/L，对照组为（25.35±7.58）μg/L，A组、B组患者血清MMP-9水平均高于对照组，A组高于B组（P﹤0.05）。绘制受试者工作特征（ROC）曲线发现，血清MMP-9水平诊断早期AD的曲线下面积为0.915，标准误为0.04，最佳临界值为48.75μg/L，取最佳临界值时血清MMP-9水平诊断早期AD的敏感度为95%，特异度为88%（ P﹤0.05）。本组60例AD患者48 h内共死亡16例，存活44例，死亡者血清MMP-9水平〔（66.98±12.52）μg/L〕高于存活者〔（45.83±9.23）μg/L，P﹤0.05〕。结论检测血清MMP-9水平有助于早期诊断AD及评估患者预后。
目的：探討血清基質金屬蛋白酶9（MMP-9）水平對早期主動脈夾層（AD）的診斷價值及預後評估作用。方法選擇2011年1月-2014年1月在廣州市第一人民醫院心內科及廣州市南沙中心醫院心內科住院的AD患者60例，根據主動脈計算機斷層掃描血管造影（ CTA）結果分為Stanford A型32例（ A組）和Stanford B型28例（ B組）；另選取同期在我院體檢健康者30例作為對照組。採用酶聯免疫吸附法（ ELISA）檢測3組受試者血清MMP-9水平。結果 A組患者血清MMP-9水平為（56.31±10.36）μg/L，B組為（45.73±9.57）μg/L，對照組為（25.35±7.58）μg/L，A組、B組患者血清MMP-9水平均高于對照組，A組高于B組（P﹤0.05）。繪製受試者工作特徵（ROC）麯線髮現，血清MMP-9水平診斷早期AD的麯線下麵積為0.915，標準誤為0.04，最佳臨界值為48.75μg/L，取最佳臨界值時血清MMP-9水平診斷早期AD的敏感度為95%，特異度為88%（ P﹤0.05）。本組60例AD患者48 h內共死亡16例，存活44例，死亡者血清MMP-9水平〔（66.98±12.52）μg/L〕高于存活者〔（45.83±9.23）μg/L，P﹤0.05〕。結論檢測血清MMP-9水平有助于早期診斷AD及評估患者預後。
목적：탐토혈청기질금속단백매9（MMP-9）수평대조기주동맥협층（AD）적진단개치급예후평고작용。방법선택2011년1월-2014년1월재엄주시제일인민의원심내과급엄주시남사중심의원심내과주원적AD환자60례，근거주동맥계산궤단층소묘혈관조영（ CTA）결과분위Stanford A형32례（ A조）화Stanford B형28례（ B조）；령선취동기재아원체검건강자30례작위대조조。채용매련면역흡부법（ ELISA）검측3조수시자혈청MMP-9수평。결과 A조환자혈청MMP-9수평위（56.31±10.36）μg/L，B조위（45.73±9.57）μg/L，대조조위（25.35±7.58）μg/L，A조、B조환자혈청MMP-9수평균고우대조조，A조고우B조（P﹤0.05）。회제수시자공작특정（ROC）곡선발현，혈청MMP-9수평진단조기AD적곡선하면적위0.915，표준오위0.04，최가림계치위48.75μg/L，취최가림계치시혈청MMP-9수평진단조기AD적민감도위95%，특이도위88%（ P﹤0.05）。본조60례AD환자48 h내공사망16례，존활44례，사망자혈청MMP-9수평〔（66.98±12.52）μg/L〕고우존활자〔（45.83±9.23）μg/L，P﹤0.05〕。결론검측혈청MMP-9수평유조우조기진단AD급평고환자예후。
Objective To investigate the diagnositic value and prognostic evaluation of matrix metalloproteinase 9 (MMP-9)on aortic dissection(AD)at early stage. Methods 60 AD patients admitted to Department of Cardiology,Nan-sha Centeral Hospital of Guangzhou and Department of Cardiology,the First People's Hospital of Guangzhou,were selected and divided into Stanford A type(group A,n=32)and Stanford B type(group B,n=28),according to aotra CTA. At the same time,30 healthy subjects were selected as control group. Serum MMP-9 levels were detected by enzyme-linked immunosorbent assay(ELISA)of the three groups. Results The serum MMP-9 level of group A was(56. 31 ±10. 36)μg/L,group B was (45. 73 ± 9. 57)μg/L,and control group was(25. 35 ± 7. 58)μg/L;serum MMP-9 levels of groups A and B were signifi-cantly higher than that of control group,group A was higher than that of group B(P﹤0. 05). ROC curve showed that the area under curve of serum MMP-9 level in diagnosis of AD at early stage was 0. 791,standard error was 0. 04,the best threshold was 48. 75 μg/L,and its sensitivity was 95%,specificity was 88%. In the 60 AD patients,16 patients died in 48 hours,44 pa-tients was alive,the serum MMP-9 level of died cases was(66. 98 ± 12. 52)μg/L,was significantly higher than that of alive cases of(45. 83 ±9. 23)μg/L(P﹤0. 05). Conclusion Detecting serum MMP-9 level is helpful in diagnosis of AD at early stage and prognosis elaluation.
