CAJ | 학술논문

建立了同时测定聚合物食品包装材料中8种常用添加剂 Irgafos 168、Irganox 1010、Irganox 1076、丁基羟基茴香醚（BHA）、没食子酸丙酯（PG）、没食子酸十二酯（ DG）、叔丁基对苯二酚（ TBHQ）和苯三唑甲酚（ UV-326）的超高效液相色谱-串联质谱方法。试样以二氯甲烷为溶剂进行超声提取；采用 Waters BEH-C18柱（50 mm ×2.1 mm，1.7μm）分离，以0.05％甲酸水溶液和甲醇为流动相进行梯度洗脱；采用电喷雾离子源正、负离子切换模式和多反应监测模式进行检测。8种添加剂在相应的质量浓度范围内定量离子的峰面积与质量浓度均呈良好线性关系（相关系数 R2均大于0.993），回收率为63.9％~127.0％，相对标准偏差（RSD，n =6）≤15.8％，检出限（ S / N =3）为0.13~5.50μg / L，定量限（S / N =10）为0.45~17.50μg / L。该方法简便快捷、灵敏度高，适合食品包装材料中常用添加剂的分析测定。
건립료동시측정취합물식품포장재료중8충상용첨가제 Irgafos 168、Irganox 1010、Irganox 1076、정기간기회향미（BHA）、몰식자산병지（PG）、몰식자산십이지（ DG）、숙정기대분이분（ TBHQ）화분삼서갑분（ UV-326）적초고효액상색보-천련질보방법。시양이이록갑완위용제진행초성제취；채용 Waters BEH-C18주（50 mm ×2.1 mm，1.7μm）분리，이0.05％갑산수용액화갑순위류동상진행제도세탈；채용전분무리자원정、부리자절환모식화다반응감측모식진행검측。8충첨가제재상응적질량농도범위내정량리자적봉면적여질량농도균정량호선성관계（상관계수 R2균대우0.993），회수솔위63.9％~127.0％，상대표준편차（RSD，n =6）≤15.8％，검출한（ S / N =3）위0.13~5.50μg / L，정량한（S / N =10）위0.45~17.50μg / L。해방법간편쾌첩、령민도고，괄합식품포장재료중상용첨가제적분석측정。
An ultra-high performance liquid chromatography-tandem mass spectrometry (UPLC-MS / MS)method was proposed for the simultaneous determination of eight additives ( Irgafos 168(tri(2. 4-di-tert-butylphenyl)phosphite),Irganox 1076(octadecyl-β-(4-hydroxy-3, 5-di-tert-butyl- phenyl)propionate),Irganox 1010(pentaerythritol tetrakys 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate),BHA( butyl hydroxy anisole),TBHQ( tertiary butylhydroqui-none),PG( propyl gallate),DG( dodecyl gallate),UV-326( 2-( 2′-hydroxyl-3′-tert-butyl-5′-methylphenyl)-5-chlorobenzotriazole ) in food packaging materials. After extracted by chlo-romethane through ultrasonic extraction,the samples were analyzed by UPLC-MS / MS. The chromatographic conditions were optimized,and the best separation was obtained on a Waters BEH-C18 column(50 mm×2. 1 mm,1. 7 μm)with gradient elution of 0. 05% acetic acid solu-tion and methanol. The analysis was performed by UPLC-MS / MS with electrospray ionization (ESI)source in switching between the positive and negative ion modes in one run for multiple reaction monitoring. The eight additives showed good linear relationships in the ranges with all the correlation coefficients(R 2 )more than 0. 993. The limits of detection(LODs,S / N = 3)and limits of quantitation(LOQs,S / N = 10)of this method were 0. 13-5. 50 μg / L and 0. 45-17. 50μg / L,respectively. The recoveries were in the range of 63. 9% - 127. 0% with all the RSDs ≤15. 8% (n = 6). This method is simple,accurate and effective for the analysis of the eight addi-tives in food packaging materials.