实用心脑肺血管病杂志
實用心腦肺血管病雜誌
실용심뇌폐혈관병잡지
PRACTICAL JOURNAL OF CARDIAC CEREBRAL PNEUMAL AND VASCULAR DISEASE
2014年
8期
42-43
,共2页
许爱东%李静%徐志强%黄国楼
許愛東%李靜%徐誌彊%黃國樓
허애동%리정%서지강%황국루
结核,肺%耐药%惠州市
結覈,肺%耐藥%惠州市
결핵,폐%내약%혜주시
Tuberculosis,pulmonary%Drug tolerance%Huizhou city
目的：分析惠州市不同年龄段肺结核患者耐药情况，为耐药肺结核的诊断与治疗提供参考依据。方法抽取2010-2013年惠州市结核病防治研究所结核科收治的肺结核患者1484例，按照年龄分为18~35岁组356例，36~59岁组612例，≥60岁组516例。回顾性分析3组患者一线抗结核药物耐药情况及耐多药情况。结果18~35岁组患者异烟肼（ INH）和链霉素（ SM）耐药率均高于36~59岁组，INH、利福平（ RFP）、SM、乙胺丁醇（ EMB）耐药率和总耐药率均高于≥60岁组（P﹤0.05）；36~59岁组患者RFP耐药率高于≥60岁组（P﹤0.05）。18~35岁组患者耐多药率高于36~59岁组，耐3药、耐4药和耐多药率高于≥60岁组（ P﹤0.05）。结论惠州市不同年龄段肺结核患者耐药情况存在较大差异，青年患者容易形成获得性耐药，需采取有针对性的预防和监控措施。
目的：分析惠州市不同年齡段肺結覈患者耐藥情況，為耐藥肺結覈的診斷與治療提供參攷依據。方法抽取2010-2013年惠州市結覈病防治研究所結覈科收治的肺結覈患者1484例，按照年齡分為18~35歲組356例，36~59歲組612例，≥60歲組516例。迴顧性分析3組患者一線抗結覈藥物耐藥情況及耐多藥情況。結果18~35歲組患者異煙肼（ INH）和鏈黴素（ SM）耐藥率均高于36~59歲組，INH、利福平（ RFP）、SM、乙胺丁醇（ EMB）耐藥率和總耐藥率均高于≥60歲組（P﹤0.05）；36~59歲組患者RFP耐藥率高于≥60歲組（P﹤0.05）。18~35歲組患者耐多藥率高于36~59歲組，耐3藥、耐4藥和耐多藥率高于≥60歲組（ P﹤0.05）。結論惠州市不同年齡段肺結覈患者耐藥情況存在較大差異，青年患者容易形成穫得性耐藥，需採取有針對性的預防和鑑控措施。
목적：분석혜주시불동년령단폐결핵환자내약정황，위내약폐결핵적진단여치료제공삼고의거。방법추취2010-2013년혜주시결핵병방치연구소결핵과수치적폐결핵환자1484례，안조년령분위18~35세조356례，36~59세조612례，≥60세조516례。회고성분석3조환자일선항결핵약물내약정황급내다약정황。결과18~35세조환자이연정（ INH）화련매소（ SM）내약솔균고우36~59세조，INH、리복평（ RFP）、SM、을알정순（ EMB）내약솔화총내약솔균고우≥60세조（P﹤0.05）；36~59세조환자RFP내약솔고우≥60세조（P﹤0.05）。18~35세조환자내다약솔고우36~59세조，내3약、내4약화내다약솔고우≥60세조（ P﹤0.05）。결론혜주시불동년령단폐결핵환자내약정황존재교대차이，청년환자용역형성획득성내약，수채취유침대성적예방화감공조시。
Objective To analysis the drug resistance in patients with pulmonary tuberculosis at different ages in Huizhou city,to provide references for diagnosis and treatment of drug resistant tuberculosis. Methods From 2010 to 2013,1 484 pulmonary tuberculosis patients were randomly chosen in the Tuberculosis Institute of Huizhou,and then divided into 18-35 years old group of 356 cases,36-59 years old group of 612 cases,≥60 years old group of 516 cases. The drug resistant rate of first-line anti-tuberculosis drugs and multi-drugs resistant rate of 3 groups were retrospectively analyzed. Results INH and SM resistant rates of 18-35 years old group were higher than those of 36-59 years old group,INH,RFP,SM,EMB resistant rates and total drug resistant rate were higher than those of ≥60 years old group(P﹤0. 05);the RFP resistant rate in 36-59 years old group was higher than that of ≥60 years old group ( P﹤0. 05 ) . The multi-drugs resistant rate of 18 -35 year old group was higher than that of 36-59 years old group,3 drugs resistant rate,4 drugs resistant rate and multi-drugs resistant rate were higher than those of≥60 years old group(P﹤0. 05). Conclusion There is a big difference of drug resistance in patients with pulmonary tuberculosis at different ages in Huizhou city,while young patients are easy to get acquired drug resistance,for which is necessary to take individual measures to prevent and control.
