国际眼科杂志
國際眼科雜誌
국제안과잡지
INTERNATIONAL JOURNAL OF OPHTHALMOLOGY
2014年
8期
1522-1524
,共3页
宋莉%张秀荣%杜治国%闫斌%赵敏
宋莉%張秀榮%杜治國%閆斌%趙敏
송리%장수영%두치국%염빈%조민
黄斑水肿%光动力疗法%光学相干断层成像%脉络膜新生血管
黃斑水腫%光動力療法%光學相榦斷層成像%脈絡膜新生血管
황반수종%광동력요법%광학상간단층성상%맥락막신생혈관
macular edema%photodynamic therapy%optical coherence tomography%choroidal neovascularization
目的：观察光学相干断层扫描( optical coherence tomography,OCT)评估光动力疗法( photodynamic therapy, PDT)治疗老年黄斑变性( age-related macular degeneration, AMD)、病理性近视( pathological myopia, PM)和中心性渗出性脉络膜视网膜病变( central exudative chorioretinopathy,CEC)引起的脉络膜新生血管( choroidal neovascularization,CNV)视网膜的疗效和安全性。
<br> 方法：回顾分析2010-01/2012-12经视力、眼压、荧光素眼底血管造影( fundus fluorescein angiography,FFA)、吲哚青绿血管造影( indocyanine green angiography, ICGA )和OCT检查,临床确诊为有CNV形成的临床患者资料,共53例53眼符合条件纳入观察。患者经PDT治疗后,每3 mo进行随访复查,复发的患者再次进行PDT治疗。对比分析治疗前与治疗后1 a患者最佳矫正视力( BCVA )及黄斑中心视网膜厚度( central macular thickness,CMT)的改变。
<br> 结果：截止随访结束时,患者经PDT治疗后,最佳矫正视力均比治疗前提高35例,视力稳定无明显变化15例,视力下降3例；所有患者眼底渗漏均减轻,经FFA检查42例患者CNV闭合且渗漏完全停止,11例患者CNV大部分闭合。治疗前后患者视力及CMT改变均有统计学意义。整个治疗及随访中所有患者均未见与接受PDT治疗相关的眼部和全身不良反应。
<br> 结论：PDT治疗AMD患者CNV能够在1 a内保持视力的稳定,且严重不良事件的发生率低,是AMD 患者CNV治疗的安全有效方法。
目的：觀察光學相榦斷層掃描( optical coherence tomography,OCT)評估光動力療法( photodynamic therapy, PDT)治療老年黃斑變性( age-related macular degeneration, AMD)、病理性近視( pathological myopia, PM)和中心性滲齣性脈絡膜視網膜病變( central exudative chorioretinopathy,CEC)引起的脈絡膜新生血管( choroidal neovascularization,CNV)視網膜的療效和安全性。
<br> 方法：迴顧分析2010-01/2012-12經視力、眼壓、熒光素眼底血管造影( fundus fluorescein angiography,FFA)、吲哚青綠血管造影( indocyanine green angiography, ICGA )和OCT檢查,臨床確診為有CNV形成的臨床患者資料,共53例53眼符閤條件納入觀察。患者經PDT治療後,每3 mo進行隨訪複查,複髮的患者再次進行PDT治療。對比分析治療前與治療後1 a患者最佳矯正視力( BCVA )及黃斑中心視網膜厚度( central macular thickness,CMT)的改變。
<br> 結果：截止隨訪結束時,患者經PDT治療後,最佳矯正視力均比治療前提高35例,視力穩定無明顯變化15例,視力下降3例；所有患者眼底滲漏均減輕,經FFA檢查42例患者CNV閉閤且滲漏完全停止,11例患者CNV大部分閉閤。治療前後患者視力及CMT改變均有統計學意義。整箇治療及隨訪中所有患者均未見與接受PDT治療相關的眼部和全身不良反應。
<br> 結論：PDT治療AMD患者CNV能夠在1 a內保持視力的穩定,且嚴重不良事件的髮生率低,是AMD 患者CNV治療的安全有效方法。
목적：관찰광학상간단층소묘( optical coherence tomography,OCT)평고광동력요법( photodynamic therapy, PDT)치료노년황반변성( age-related macular degeneration, AMD)、병이성근시( pathological myopia, PM)화중심성삼출성맥락막시망막병변( central exudative chorioretinopathy,CEC)인기적맥락막신생혈관( choroidal neovascularization,CNV)시망막적료효화안전성。
<br> 방법：회고분석2010-01/2012-12경시력、안압、형광소안저혈관조영( fundus fluorescein angiography,FFA)、신타청록혈관조영( indocyanine green angiography, ICGA )화OCT검사,림상학진위유CNV형성적림상환자자료,공53례53안부합조건납입관찰。환자경PDT치료후,매3 mo진행수방복사,복발적환자재차진행PDT치료。대비분석치료전여치료후1 a환자최가교정시력( BCVA )급황반중심시망막후도( central macular thickness,CMT)적개변。
<br> 결과：절지수방결속시,환자경PDT치료후,최가교정시력균비치료전제고35례,시력은정무명현변화15례,시력하강3례；소유환자안저삼루균감경,경FFA검사42례환자CNV폐합차삼루완전정지,11례환자CNV대부분폐합。치료전후환자시력급CMT개변균유통계학의의。정개치료급수방중소유환자균미견여접수PDT치료상관적안부화전신불량반응。
<br> 결론：PDT치료AMD환자CNV능구재1 a내보지시력적은정,차엄중불량사건적발생솔저,시AMD 환자CNV치료적안전유효방법。
AIM: To evaluate the clinical efficacy and safety of photodynamic therapy ( PDT ) on choroidal neovascularization ( CNV) caused by age-related macular degeneration ( AMD ) , pathological myopia ( PM ) , and central exudative chorioretinopathy ( CEC) .
<br> METHODS: A retrospective observation on the clinical data of 53 AMD patients ( 53 eyes ) from January 2010 to December 2012, diagnosed CNV through fundus fluorescein angiography ( FFA ) , indocyanine green angiography ( ICGA ) and optic coherence tomography ( OCT) , treated with PDT. The changes of best corrected visual acuity ( BCVA ) and central macular thickness (CMT) were compared before and 1a after treatment.
<br> RESULTS: At the last follow - up, the BCVA was improved in 35 cases, stabilized in 15 cases and decreased in 3 cases. Fundus hemorrhage and exudation reduction after PDT was observed in all patients. FFA and OCT showed complete closure of CNV in 42 cases, partial closure in 11 cases. The visual acuity and CMT changes were statistically significant. No serious adverse event related to PDT.
<br> CONCLUSION:PDT is helpful for maintaining the visual acuity of wet-AMD within 1a and the incidence of the adverse response is low, which suggest that PDT is an effective and safe treatment for CNV in patients of AMD.
