国际眼科杂志
國際眼科雜誌
국제안과잡지
INTERNATIONAL JOURNAL OF OPHTHALMOLOGY
2014年
8期
1484-1487
,共4页
屈光参差性%弱视儿童%色觉%血氧水平依赖性功能磁共振成像
屈光參差性%弱視兒童%色覺%血氧水平依賴性功能磁共振成像
굴광삼차성%약시인동%색각%혈양수평의뢰성공능자공진성상
anisometropia%amblyopic children%color vision%blood oxygen level dependence - functional magnetic resonance imaging
目的：利用血氧水平依赖性功能磁共振成像( blood oxygen level dependence-functional magnetic resonance imaging, BOLD-fMRI)及SPM8软件研究分析经过系统治疗后屈光参差性弱视儿童色觉中枢激活区域的恢复情况。<br> 方法：自身前后对照研究。利用3.0T超导磁共振采集13例屈光参差性弱视儿童色觉中枢激活区域的试验数据,采用组块设计方案,以三原色作为刺激源获取色觉皮层激活区功能核磁共振数据,应用基于MATLAB 软件下的运行的SPM8对数据进行预处理及分析,对比初诊、治疗1,2,4 wk后色觉中枢激活区域的变化。<br> 结果：弱视初诊患儿接受三原色刺激后, BA17, BA18, BA19,BA37均有不同范围的激活(P<0.01)。经过4wk治疗后,弱视患儿接受红色刺激后,视觉皮层激活范围无扩大；接受绿色刺激后,视觉皮层左侧BA37、左侧BA19、左侧BA20激活范围均有不同程度扩大,平均t值分别为3.5210,3.2716,3.1534( P<0.01)；接受蓝色刺激后,视觉皮层右侧BA19、右侧BA18激活范围有不同程度扩大,平均t值分别为3.7345,3.2701( P<0.01)。<br> 结论：经过4 wk的系统治疗后屈光参差性弱视儿童色觉中枢激活范围较初诊时增大但幅度较低,经短期治疗弱视患儿色觉中枢有一定程度的恢复但不明显。
目的：利用血氧水平依賴性功能磁共振成像( blood oxygen level dependence-functional magnetic resonance imaging, BOLD-fMRI)及SPM8軟件研究分析經過繫統治療後屈光參差性弱視兒童色覺中樞激活區域的恢複情況。<br> 方法：自身前後對照研究。利用3.0T超導磁共振採集13例屈光參差性弱視兒童色覺中樞激活區域的試驗數據,採用組塊設計方案,以三原色作為刺激源穫取色覺皮層激活區功能覈磁共振數據,應用基于MATLAB 軟件下的運行的SPM8對數據進行預處理及分析,對比初診、治療1,2,4 wk後色覺中樞激活區域的變化。<br> 結果：弱視初診患兒接受三原色刺激後, BA17, BA18, BA19,BA37均有不同範圍的激活(P<0.01)。經過4wk治療後,弱視患兒接受紅色刺激後,視覺皮層激活範圍無擴大；接受綠色刺激後,視覺皮層左側BA37、左側BA19、左側BA20激活範圍均有不同程度擴大,平均t值分彆為3.5210,3.2716,3.1534( P<0.01)；接受藍色刺激後,視覺皮層右側BA19、右側BA18激活範圍有不同程度擴大,平均t值分彆為3.7345,3.2701( P<0.01)。<br> 結論：經過4 wk的繫統治療後屈光參差性弱視兒童色覺中樞激活範圍較初診時增大但幅度較低,經短期治療弱視患兒色覺中樞有一定程度的恢複但不明顯。
목적：이용혈양수평의뢰성공능자공진성상( blood oxygen level dependence-functional magnetic resonance imaging, BOLD-fMRI)급SPM8연건연구분석경과계통치료후굴광삼차성약시인동색각중추격활구역적회복정황。<br> 방법：자신전후대조연구。이용3.0T초도자공진채집13례굴광삼차성약시인동색각중추격활구역적시험수거,채용조괴설계방안,이삼원색작위자격원획취색각피층격활구공능핵자공진수거,응용기우MATLAB 연건하적운행적SPM8대수거진행예처리급분석,대비초진、치료1,2,4 wk후색각중추격활구역적변화。<br> 결과：약시초진환인접수삼원색자격후, BA17, BA18, BA19,BA37균유불동범위적격활(P<0.01)。경과4wk치료후,약시환인접수홍색자격후,시각피층격활범위무확대；접수록색자격후,시각피층좌측BA37、좌측BA19、좌측BA20격활범위균유불동정도확대,평균t치분별위3.5210,3.2716,3.1534( P<0.01)；접수람색자격후,시각피층우측BA19、우측BA18격활범위유불동정도확대,평균t치분별위3.7345,3.2701( P<0.01)。<br> 결론：경과4 wk적계통치료후굴광삼차성약시인동색각중추격활범위교초진시증대단폭도교저,경단기치료약시환인색각중추유일정정도적회복단불명현。
AIM:To analyze the recovery of visual cortex activation range of color vision in anisometropia amblyopia children after treatment by using blood oxygen level dependence-functional magnetic resonance imaging ( BOLD- fMRI ) and SPM8 software. <br> METHODS:Self-control study. This fMRI study directly compared activity in visual cortex produced by color monocular stimulation in 13 monocular anisometropia amblyopia children. The project of study was blocked design. The data of functions and anatomical MRI was stimulated by three-primary colors and was preprocessed and analyzed by SPM8 that based on MATLAB software. According to the data, we compared the change of the central area of color vision when first visit and 1, 2 ,4wk after treatment. <br> RESULTS: The BA17, BA18, BA19 and BA37 of amblyopia children were different activated after they accepted the three-primary colors stimulation (P<0. 01). After 4wk treatment, amblyopia children accepted red stimulation, the visual cortex activation range without expanding; after accepting green stimulus, on the left side of the visual cortex BA37, BA19, BA20, the average t value were 3. 5210, 3. 2716, 3. 1534 ( P< 0. 01 ); after accepting blue stimulation, the scope of the right side of visual cortex at BA19, BA18 were expanded to different extent, the average t value were 3. 7345, 3. 2701 (P<0. 01). <br> CONCLUSION: After 4wk treatment, visual cortex activation of color vision of anisometropia amblyopic children is expanded, but with low extent, after the short-term treatment of amblyopia, visual cortex activation of color vision has a certain degree of recovery but not obvious.
