CAJ | 학술논문

代谢组学技术作为一种新的组学研究手段，能够揭示肝细胞癌（HCC）发生发展过程中的代谢谱差异，成为HCC生物标志物研究的热点。简述了代谢组学在HCC诊断中的意义，概括了HCC相关的生物标志物的代谢组学研究，这些研究主要以血清、尿液及肝组织代谢物为对象，通过动物实验和临床研究两个方面进行。指出分析和监视HCC发生发展过程中相应代谢物的变化，对于患者的个体化治疗具有重要价值。
대사조학기술작위일충신적조학연구수단，능구게시간세포암（HCC）발생발전과정중적대사보차이，성위HCC생물표지물연구적열점。간술료대사조학재HCC진단중적의의，개괄료HCC상관적생물표지물적대사조학연구，저사연구주요이혈청、뇨액급간조직대사물위대상，통과동물실험화림상연구량개방면진행。지출분석화감시HCC발생발전과정중상응대사물적변화，대우환자적개체화치료구유중요개치。
As a novel research tool,metabolomics technology can reveal the differences in metabolic profiles during the development and progression of hepatocellular carcinoma (HCC),so it has been widely applied for research on HCC biomarkers.The significance of metabo-lomics in the diagnosis of HCC is briefly described,and the metabolomics research aiming at the discovery of HCC biomarkers,including an-imal experiments and clinical studies of metabolites in the serum,urine,and liver tissue,is reviewed.It is pointed out that analyzing and monitoring metabolites in the development and progression of HCC is of great significance for individualized treatment.