CAJ | 학술논문

HBV在复制过程中存在着共价闭合环状DNA（cccDNA）形式，cccDNA是HBV复制的原始模板，是HBV持续感染的主要原因，也是HBV一个重要生物活性指标。HBV是嗜肝病毒，但可能存在肝外感染，有研究表明，外周血单核细胞（PBMC）中可以检测到HBV cccDNA。归纳了PBMC中HBV cccDNA在乙型肝炎患者肝移植术后及抗病毒治疗后HBV复发、HBV母婴传播中的预测作用，以及其参与HBV肝外感染的可能机制。由此可见，PBMC HBV cccDNA在HBV的治疗及研究中有重要意义。
HBV재복제과정중존재착공개폐합배상DNA（cccDNA）형식，cccDNA시HBV복제적원시모판，시HBV지속감염적주요원인，야시HBV일개중요생물활성지표。HBV시기간병독，단가능존재간외감염，유연구표명，외주혈단핵세포（PBMC）중가이검측도HBV cccDNA。귀납료PBMC중HBV cccDNA재을형간염환자간이식술후급항병독치료후HBV복발、HBV모영전파중적예측작용，이급기삼여HBV간외감염적가능궤제。유차가견，PBMC HBV cccDNA재HBV적치료급연구중유중요의의。
Hepatitis B virus (HBV)covalently closed circular DNA (cccDNA)is an intermediate replicative episome which is stable and not easy to eliminate.cccDNA serves as the template for HBV replication and plays an important role in persistence of HBV infection in hep-atocytes,and it is also a biomarker of HBV activity.Studies suggested that HBV has extrahepatic infectivity and cccDNA could be detected in peripheral blood mononuclear cells (PBMC).The predictive values of HBV cccDNA in PBMC for HBV recurrence after liver transplanta-tion and antiviral therapy and mother-to -child transmission of HBV in patients with hepatitis B,as well as the possible mechanism of cccDNA involved in extrahepatic HBV infection,are summarized.Therefore,the detection of HBV cccDNA is of great significance for the study and treatment of HBV.