CAJ | 학술논문

近年来，越来越多的研究表明，血管收缩、血液分流、灌注不足、血液黏滞度增加以及血液凝固等微循环障碍与急性胰腺炎（AP）的发病机制密切相关。缺血再灌注损伤及氧自由基的不断产生亦可加速AP的进程。介绍了胰腺微循环的解剖学特征、胰腺微循环障碍的病理生理学机制及相关的炎症介质，以及AP微循环障碍的治疗进展，提示胰腺及全身微循环障碍可能在AP发生发展中起着重要的作用。
근년래，월래월다적연구표명，혈관수축、혈액분류、관주불족、혈액점체도증가이급혈액응고등미순배장애여급성이선염（AP）적발병궤제밀절상관。결혈재관주손상급양자유기적불단산생역가가속AP적진정。개소료이선미순배적해부학특정、이선미순배장애적병리생이학궤제급상관적염증개질，이급AP미순배장애적치료진전，제시이선급전신미순배장애가능재AP발생발전중기착중요적작용。
In recent years,there has been increasing evidence that microcirculatory disturbance,including vasoconstriction,shunting,inad-equate perfusion,increased blood viscosity,and coagulation,is closely associated with the pathogenesis of acute pancreatitis (AP).These processes may be exacerbated by ischaemia-reperfusion injury and the generation of oxygen radicals.The anatomical features of pancreatic microcirculation,the pathophysiological mechanism of pancreatic microcirculation disturbance and related inflammatory mediators,and pro-gress in the treatment of microcirculatory disturbance in AP are reviewed.It is suggested that the pancreatic and systemic microcirculation may play a key role in the development and progression of AP.