CAJ | 학술논문

胰腺癌是消化系统常见的恶性肿瘤之一，恶性程度高，诊断时往往已是晚期，预后极差。数年来流行病学研究显示糖尿病与胰腺癌关系密切，近年来的多项临床回顾性研究以及分子机制研究对糖尿病与胰腺癌的关系有了新的认识，尤其是新发糖尿病与胰腺癌的关系，抗糖尿病药物对胰腺癌的作用，胰腺癌与糖尿病相互关联的分子基础等。目前认为长期糖尿病是胰腺癌发生的危险因素之一，新发糖尿病可能帮助早期诊断胰腺癌，糖尿病本身可能影响胰腺癌的预后，而抗糖尿病药物的不同选择亦可能影响胰腺癌发生概率，对糖尿病促进胰腺癌分子机制的研究则有助于寻找胰腺癌治疗的新靶点。
이선암시소화계통상견적악성종류지일，악성정도고，진단시왕왕이시만기，예후겁차。수년래류행병학연구현시당뇨병여이선암관계밀절，근년래적다항림상회고성연구이급분자궤제연구대당뇨병여이선암적관계유료신적인식，우기시신발당뇨병여이선암적관계，항당뇨병약물대이선암적작용，이선암여당뇨병상호관련적분자기출등。목전인위장기당뇨병시이선암발생적위험인소지일，신발당뇨병가능방조조기진단이선암，당뇨병본신가능영향이선암적예후，이항당뇨병약물적불동선택역가능영향이선암발생개솔，대당뇨병촉진이선암분자궤제적연구칙유조우심조이선암치료적신파점。
Pancreatic cancer (PC)is one of common malignant digestive diseases.It is mostly diagnosed at advanced stage,with an ex-tremely poor progression.The relationship between diabetes and PC was shown by numerous epidemiological studies for decades.Retrospec-tive clinical studies and research on molecular mechanisms in recent years have led to a new understanding of the relationship between diabe-tes,especially new-onset diabetes,and PC,the effect of antidiabetic medication on PC,and the molecular mechanisms underlying the con-nection between diabetes and PC.It is suggested by recent data that long-standing diabetes is one of the risk factors for PC development, new-onset diabetes may facilitate early diagnosis of PC,diabetes may have an impact on the prognosis of PC,the option of antidiabetic medication may influence the incidence of PC,and exploring the molecular mechanisms underlying the association between diabetes and PC may help to identify the new therapeutic target for PC.