CAJ | 학술논문

目的：探讨内镜止血联合大剂量质子泵抑制剂治疗急性非静脉曲张性上消化道出血的临床效果。方法选取本院2011年10月～2013年10月诊治的急性非静脉曲张性上消化道出血患者148例，根据治疗方案分为两组，74例患者采用大剂量质子泵抑制剂治疗为对照组，74例患者采用内镜止血联合大剂量质子泵抑制剂治疗为观察组，比较两组患者的止血效果与预后情况。结果观察组患者止血时间、输血量、住院时间均明显小于对照组，观察组患者剖腹手术率、再出血率均明显低于对照组，差异均有统计学意义（ P＜0.05）。结论内镜止血联合大剂量质子泵抑制剂是治疗急性非静脉曲张性上消化道出血的有效方法，可明显缩短患者的止血时间，显著提高疾病的治疗效果，值得临床推广使用。
목적：탐토내경지혈연합대제량질자빙억제제치료급성비정맥곡장성상소화도출혈적림상효과。방법선취본원2011년10월～2013년10월진치적급성비정맥곡장성상소화도출혈환자148례，근거치료방안분위량조，74례환자채용대제량질자빙억제제치료위대조조，74례환자채용내경지혈연합대제량질자빙억제제치료위관찰조，비교량조환자적지혈효과여예후정황。결과관찰조환자지혈시간、수혈량、주원시간균명현소우대조조，관찰조환자부복수술솔、재출혈솔균명현저우대조조，차이균유통계학의의（ P＜0.05）。결론내경지혈연합대제량질자빙억제제시치료급성비정맥곡장성상소화도출혈적유효방법，가명현축단환자적지혈시간，현저제고질병적치료효과，치득림상추엄사용。
Objective To investigate clinical effect of endoscopic hemostasis combined with high dose PPIs in treatment for ANVUGIB. Methods 148 patients with ANVUGIB were selected in hospital from October 2011 to October 2013. According to treatment, patients were divided into two groups. 74 patients treated high dose PPIs as control group. 74 patients treated endoscopic hemostasis combined with high dose PPIs as observation group. Hemostatic effect and prognosis were compared between two groups. Results Hemostatic time, volume of blood transfusion, hospitalization time in observation group were significantly less than control group. Caesarean operation rate and rebleeding rate in observation group were significantly lower than control group. Differences were statistically significant (P<0.05). Conclusion Endoscopic hemostasis combined with high dose PPIs are effective methods in treatment for ANVUGIB, which can significantly shorten hemostatic time and improve treatment effect. Endoscopic hemostasis combined with high dose PPIs are worthy of clinical use.