中国医药科学
中國醫藥科學
중국의약과학
CHINA MEDICINE AND PHARMACY
2014年
11期
102-104
,共3页
地佐辛%瑞芬太尼%痛觉过敏%不良反应
地佐辛%瑞芬太尼%痛覺過敏%不良反應
지좌신%서분태니%통각과민%불량반응
Dezocine%Remifentanil%Hyperalgesia%Adverse reactions
目的：观察地佐辛是否有预防瑞芬太尼复合全麻苏醒期疼痛过敏的作用。方法选取择期行腹腔镜下胆囊切除手术（LC）患者60例，美国麻醉医师协会（ASA）分级Ⅰ～Ⅱ级，按数字表法随机分为对照组30例、观察组30例。对照组在瑞芬太尼停药前后不给任何镇痛药物，观察组在瑞芬太尼停药前15 min静脉注射地佐辛10 mg。记录两组患者苏醒即刻（T1）、苏醒后（T2）HR、MAP及苏醒时间，并采用Prince-henry疼痛评分法对患者进行手术后疼痛评分。结果两组患者苏醒时间差异无统计学意义（P＞0.05）。观察组HR、MAP在T1、T2时间点均无明显变化（P均＞0.05），对照组HR、MAP在T2时间点明显高于T1（P＜0.05），观察组H R、MAP 在 T2时间点均明显低于对照组（P 均＜0.05），观察组手术后疼痛评分明显低于对照组（ P ＜0.01）。结论地佐辛可以预防瑞芬太尼复合全麻苏醒期疼痛过敏，减少瑞芬太尼复合全麻苏醒期不良反应。
目的：觀察地佐辛是否有預防瑞芬太尼複閤全痳囌醒期疼痛過敏的作用。方法選取擇期行腹腔鏡下膽囊切除手術（LC）患者60例，美國痳醉醫師協會（ASA）分級Ⅰ～Ⅱ級，按數字錶法隨機分為對照組30例、觀察組30例。對照組在瑞芬太尼停藥前後不給任何鎮痛藥物，觀察組在瑞芬太尼停藥前15 min靜脈註射地佐辛10 mg。記錄兩組患者囌醒即刻（T1）、囌醒後（T2）HR、MAP及囌醒時間，併採用Prince-henry疼痛評分法對患者進行手術後疼痛評分。結果兩組患者囌醒時間差異無統計學意義（P＞0.05）。觀察組HR、MAP在T1、T2時間點均無明顯變化（P均＞0.05），對照組HR、MAP在T2時間點明顯高于T1（P＜0.05），觀察組H R、MAP 在 T2時間點均明顯低于對照組（P 均＜0.05），觀察組手術後疼痛評分明顯低于對照組（ P ＜0.01）。結論地佐辛可以預防瑞芬太尼複閤全痳囌醒期疼痛過敏，減少瑞芬太尼複閤全痳囌醒期不良反應。
목적：관찰지좌신시부유예방서분태니복합전마소성기동통과민적작용。방법선취택기행복강경하담낭절제수술（LC）환자60례，미국마취의사협회（ASA）분급Ⅰ～Ⅱ급，안수자표법수궤분위대조조30례、관찰조30례。대조조재서분태니정약전후불급임하진통약물，관찰조재서분태니정약전15 min정맥주사지좌신10 mg。기록량조환자소성즉각（T1）、소성후（T2）HR、MAP급소성시간，병채용Prince-henry동통평분법대환자진행수술후동통평분。결과량조환자소성시간차이무통계학의의（P＞0.05）。관찰조HR、MAP재T1、T2시간점균무명현변화（P균＞0.05），대조조HR、MAP재T2시간점명현고우T1（P＜0.05），관찰조H R、MAP 재 T2시간점균명현저우대조조（P 균＜0.05），관찰조수술후동통평분명현저우대조조（ P ＜0.01）。결론지좌신가이예방서분태니복합전마소성기동통과민，감소서분태니복합전마소성기불량반응。
Objective To observe the effects of dezocine whether in preventing hyperalgesic action during recovery period of remifentanil composite general anesthesia. Methods According to the digital table,60 patients underwent laparoscopic cholecystectomy operation (LC),which American anesthesiologists (ASA) grade inⅠtoⅡ,were randomly divided into the control group and the observation group,each group 30 cases.Before and after drug discontinuation in remifentanil,the control group was not given any analgesic drug,while before 15 minute of drug discontinuation in remifentanil the observation group was given intravenous dezocine 10 mg.The HR, MAP at immediately(T1), wake up wake(T2) and recovery time of the two groups were recorded,and using the Prince-henry pain score method for patients after operation pain score. Results The two groups had no statistically significant difference between the patients recovery time (P>0.05).The observation group HR,MAP in T1,T2 time point showed no significant change (P>0.05),control group HR,MAP at T2 time point was significantly higher than that of T1 (P<0.05),were observed in group HR,MAP in T2 time points were significantly lower than that of control group(all P < 0.05),see table 1.To observe the pain score of group after operation was significantly lower than the control group (P<0.01). Conclusion Dezocine can prevent preventing hyperalgesic action during recovery period of remifentanil composite general anesthesia,and reduce the adverse reaction of remifentanil anesthesia recovery period.
