CAJ | 학술논문

目的：探讨氯吡格雷联合阿司匹林与单用阿司匹林预防脑缺血患者临床疗效及安全性。方法80例患者随机分为氯吡格雷联合阿司匹林治疗组、阿司匹林对照组,每组40例。阿司匹林组口服阿司匹林100mg，每日1次；治疗组给予氯吡格雷75mg，阿司匹林100mg，每日1次，随访3个月，统计分析两组患者脑缺血发生率，总结临床疗效。结果治疗组与对照组比较，治疗组脑缺血事件复发的发生率低于对照组，且有统计学意义。结论阿司匹林与氯吡格雷联合使用具有协同拮抗血小板作用,可显著降低脑血管缺血事件的发生率，且副作用少、安全可靠。
목적：탐토록필격뢰연합아사필림여단용아사필림예방뇌결혈환자림상료효급안전성。방법80례환자수궤분위록필격뢰연합아사필림치료조、아사필림대조조,매조40례。아사필림조구복아사필림100mg，매일1차；치료조급여록필격뢰75mg，아사필림100mg，매일1차，수방3개월，통계분석량조환자뇌결혈발생솔，총결림상료효。결과치료조여대조조비교，치료조뇌결혈사건복발적발생솔저우대조조，차유통계학의의。결론아사필림여록필격뢰연합사용구유협동길항혈소판작용,가현저강저뇌혈관결혈사건적발생솔，차부작용소、안전가고。
Objective To compare the clinical effect and safety of clopidogrel plus aspirin and aspirin alone in the prevention of cerebral ischemia. Methods 80 patients were randomly allocated to a treatment group of clopidogrel plus aspirin and an aspirin group, with 40 patients in each. The aspirin group was orally given aspirin of 100mg once a day; the treatment group was given clopidogrel of 75mg and aspirin of 100mg once a day. The follow-up lasted for 3 months. Incidence of cerebral ischemia in the two groups were calculated and analyzed, and clinical effect was then summarized. Results Compared with the control group, the incidence of relapses of cerebral ischemia in the treatment group was lower than that in the control group, and the difference was statistically significant. Conclusion The combined use of aspirin and clopidogrel has the function of collaboratively antagonizing platelets, and therefore significantly reduces the incidence of cerebral ischemia. It also causes less side effects and is thus safe and reliable.