CAJ | 학술논문

目的：探讨血浆脂蛋白磷脂酶A2水平对冠心病合并2型糖尿病患者的影响。方法选取2012年1月～2014年1月间在我院接受诊断和治疗的70例冠心病合并2型糖尿病患者作为实验组，同时选取同期入院的70例2型糖尿病患者作为对照组，对照组患者无冠心病。两组患者在性别、年龄、病程等方面差异不明显（P＞0.05），具有可比性。用ELISA双抗体夹心法检测患者血浆Lp-PLA2活性。结果实验组的Lp-PLA2平均活性明显高于对照组；肥胖因素、性别因素、高密度脂蛋白代谢紊乱、低密度脂蛋白代谢紊乱、吸烟因素都可以明显影响Lp-PLA2平均活性。结论 LP-PLA2参与多种病理生理过程，多种因素可以影响其活性，因而可以通过合理控制这些危险因素进而控制冠心病合并2型糖尿病的发展。
목적：탐토혈장지단백린지매A2수평대관심병합병2형당뇨병환자적영향。방법선취2012년1월～2014년1월간재아원접수진단화치료적70례관심병합병2형당뇨병환자작위실험조，동시선취동기입원적70례2형당뇨병환자작위대조조，대조조환자무관심병。량조환자재성별、년령、병정등방면차이불명현（P＞0.05），구유가비성。용ELISA쌍항체협심법검측환자혈장Lp-PLA2활성。결과실험조적Lp-PLA2평균활성명현고우대조조；비반인소、성별인소、고밀도지단백대사문란、저밀도지단백대사문란、흡연인소도가이명현영향Lp-PLA2평균활성。결론 LP-PLA2삼여다충병리생리과정，다충인소가이영향기활성，인이가이통과합리공제저사위험인소진이공제관심병합병2형당뇨병적발전。
Objective To investigate the influence of plasma lipoprotein-associated phospholipase A2 (Lp-PLA2) in patients with both coronary heart disease (CHD) and type 2 diabetes (T2D). Methods Seventy cases of patients with CHD and T2D diagnosed and treated in Dongguan Shijie Hospital from January 2012 to January 2014 were used as the experimental group,whereas another 70 cases of T2D patients without CHD that were treated in the same hospital in the same period were used as control group.The patients in the two groups had similar gender ratio,age,and pathologic phases without any significantly difference(P > 0.05).The plasma Lp-PLA2 activity of all these patients was detected using the sandwich ELISA method. Results The average Lp-PLA2 activity of patients in the experimental group was significantly higher than that of patients in the control group,and it could be affected by factors,such as obesity,gender, metabolic disorders of high density lipoprotein (HDLP) and low-density lipoprotein (LDLP),as well as smoking. Conclusion Lp-PLA2 is involved in various pathophysiological processes and its activity could be affected by several factors,which indicate that it could be a reasonable strategy to control the progress of CHD and T2D by reasonably controlling these risk factors.