中国医药科学
中國醫藥科學
중국의약과학
CHINA MEDICINE AND PHARMACY
2014年
12期
73-75,81
,共4页
特应性皮炎%成人期%1％吡美莫司乳膏%地奈德乳膏%生活质量
特應性皮炎%成人期%1％吡美莫司乳膏%地奈德乳膏%生活質量
특응성피염%성인기%1％필미막사유고%지내덕유고%생활질량
Atopic dermatitis%Adult%1％pimecrolimus cream%Desonide cream%Life quality
目的：探讨1%吡美莫司乳膏联合地奈德乳膏治疗青年成人期特应性皮炎的疗效及生活质量评价。方法64例成人期特应性皮炎患者分为观察组和对照组各32例，对照组予地奈德乳膏涂患处，观察组联合l%吡美莫司乳膏，连续治疗3周。比较两组的疗效及皮损面积、瘙痒的临床症状评分、生活质量DLQI 的变化。结果观察组临床治愈率达21.8%、观察组治疗后的总有效率达90.6%，分别显著高于对照组（P＜0.05）。观察组患者治疗后瘙痒、皮损面积及临床症状总积分分比为0.32±0.07、0.39±0.14、1.73±0.26，与对照组治疗后比较，差异有统计学意义（P＜0.05）。观察组患者治疗后的症状/感觉、休闲活动、工作学习、人际关系、日常活动、治疗的影响及总影响各项评分均较对照组明显改善（P＜0.05）。结论 l%吡美莫司乳膏联合地奈德乳膏治疗青年成人期特应性皮炎的疗效确切，安全性好，可以明显改善患者的临床症状，从而提高患者的生活质量，值得推广和应用。
目的：探討1%吡美莫司乳膏聯閤地奈德乳膏治療青年成人期特應性皮炎的療效及生活質量評價。方法64例成人期特應性皮炎患者分為觀察組和對照組各32例，對照組予地奈德乳膏塗患處，觀察組聯閤l%吡美莫司乳膏，連續治療3週。比較兩組的療效及皮損麵積、瘙癢的臨床癥狀評分、生活質量DLQI 的變化。結果觀察組臨床治愈率達21.8%、觀察組治療後的總有效率達90.6%，分彆顯著高于對照組（P＜0.05）。觀察組患者治療後瘙癢、皮損麵積及臨床癥狀總積分分比為0.32±0.07、0.39±0.14、1.73±0.26，與對照組治療後比較，差異有統計學意義（P＜0.05）。觀察組患者治療後的癥狀/感覺、休閒活動、工作學習、人際關繫、日常活動、治療的影響及總影響各項評分均較對照組明顯改善（P＜0.05）。結論 l%吡美莫司乳膏聯閤地奈德乳膏治療青年成人期特應性皮炎的療效確切，安全性好，可以明顯改善患者的臨床癥狀，從而提高患者的生活質量，值得推廣和應用。
목적：탐토1%필미막사유고연합지내덕유고치료청년성인기특응성피염적료효급생활질량평개。방법64례성인기특응성피염환자분위관찰조화대조조각32례，대조조여지내덕유고도환처，관찰조연합l%필미막사유고，련속치료3주。비교량조적료효급피손면적、소양적림상증상평분、생활질량DLQI 적변화。결과관찰조림상치유솔체21.8%、관찰조치료후적총유효솔체90.6%，분별현저고우대조조（P＜0.05）。관찰조환자치료후소양、피손면적급림상증상총적분분비위0.32±0.07、0.39±0.14、1.73±0.26，여대조조치료후비교，차이유통계학의의（P＜0.05）。관찰조환자치료후적증상/감각、휴한활동、공작학습、인제관계、일상활동、치료적영향급총영향각항평분균교대조조명현개선（P＜0.05）。결론 l%필미막사유고연합지내덕유고치료청년성인기특응성피염적료효학절，안전성호，가이명현개선환자적림상증상，종이제고환자적생활질량，치득추엄화응용。
Objective To investigate the efficacy and life quality evaluation of 1% pimecrolimus cream combined with desonide cream in the treatment of atopic dermatitis in young adults. Methods Sixty-four adults with atopic dermatitis were divided into the observation group and the control group,with 32 patients in each group.The control group was given desonide cream smearing over the afflicted part and the observation group was given combined l%pimecrolimus cream for 3 continuous weeks.The efficacy and skin lesion area,clinical symptom score of itching,and change of life quality DLQI of the two groups were compared. Results In the observation group,the clinical cure rate reached 21.8% and the total effective rate after the treatment reached 90.6%,which were significantly higher than those of the control group respectively(P<0.05). The itching,skin lesion area and total clinical symptom score after the treatment of the observation group were 0.32±0.07, 0.39±0.14 and 1.73±0.26 respectively,which were significantly different from those of the control group(P < 0.05).The observation group had significantly improved scores of symptoms/feeling,leisure activities,work and study, interpersonal relationship,daily activities,treatment influence and total influence compared to the control group after the treatment(P < 0.05). Conclusion In the treatment of atopic dermatitis in young adults,1%pimecrolimus cream combined with desonide cream shows accurate efficacy and good safety and can obviously improve the patients'clinical symptoms,thus improves the patients'life quality,which is worthy of promotion and application.
