中国医药科学
中國醫藥科學
중국의약과학
CHINA MEDICINE AND PHARMACY
2014年
12期
65-67,72
,共4页
消化性溃疡%胃镜%去甲肾上腺素%奥美拉唑
消化性潰瘍%胃鏡%去甲腎上腺素%奧美拉唑
소화성궤양%위경%거갑신상선소%오미랍서
Peptic ulcer%Gastroscope%Norepinephrine%Omeprazole
目的：探讨胃镜下注射去甲肾上腺素联合奥美拉唑治疗消化性溃疡出血的疗效及安全性。方法将82例消化性溃疡出血患者随机分为观察组和对照组，每组各41例。观察组采用胃镜下注射去甲肾上腺素联合奥美拉唑治疗，对照组采用奥美拉唑联合立止血治疗。结果观察组总有效率明显高于对照组，两组比较差异有统计学意义（P＜0.05）；两组患者24h、48h及72h空腹胃液pH值逐渐升高，与治疗前相比有统计学意义（P＜0.05），且观察组升高幅度明显优于对照组（P＜0.05）；观察组患者止血时间、输液时间、住院时间均明显低于对照组（P＜0.05），输血量及住院费用较对照组明显减少（P＜0.05），再出血发生率明显低于对照组（P＜0.05）。两组均未见明显不良反应。结论胃镜下注射去甲肾上腺素联合奥美拉唑治疗消化性溃疡出血疗效确切，安全可靠，值得临床推广应用。
目的：探討胃鏡下註射去甲腎上腺素聯閤奧美拉唑治療消化性潰瘍齣血的療效及安全性。方法將82例消化性潰瘍齣血患者隨機分為觀察組和對照組，每組各41例。觀察組採用胃鏡下註射去甲腎上腺素聯閤奧美拉唑治療，對照組採用奧美拉唑聯閤立止血治療。結果觀察組總有效率明顯高于對照組，兩組比較差異有統計學意義（P＜0.05）；兩組患者24h、48h及72h空腹胃液pH值逐漸升高，與治療前相比有統計學意義（P＜0.05），且觀察組升高幅度明顯優于對照組（P＜0.05）；觀察組患者止血時間、輸液時間、住院時間均明顯低于對照組（P＜0.05），輸血量及住院費用較對照組明顯減少（P＜0.05），再齣血髮生率明顯低于對照組（P＜0.05）。兩組均未見明顯不良反應。結論胃鏡下註射去甲腎上腺素聯閤奧美拉唑治療消化性潰瘍齣血療效確切，安全可靠，值得臨床推廣應用。
목적：탐토위경하주사거갑신상선소연합오미랍서치료소화성궤양출혈적료효급안전성。방법장82례소화성궤양출혈환자수궤분위관찰조화대조조，매조각41례。관찰조채용위경하주사거갑신상선소연합오미랍서치료，대조조채용오미랍서연합립지혈치료。결과관찰조총유효솔명현고우대조조，량조비교차이유통계학의의（P＜0.05）；량조환자24h、48h급72h공복위액pH치축점승고，여치료전상비유통계학의의（P＜0.05），차관찰조승고폭도명현우우대조조（P＜0.05）；관찰조환자지혈시간、수액시간、주원시간균명현저우대조조（P＜0.05），수혈량급주원비용교대조조명현감소（P＜0.05），재출혈발생솔명현저우대조조（P＜0.05）。량조균미견명현불량반응。결론위경하주사거갑신상선소연합오미랍서치료소화성궤양출혈료효학절，안전가고，치득림상추엄응용。
Objective To evaluate the efficacy and safety of injection of norepinephrine under gastroscope combined with Omeprazole in Peptic Ulcer bleeding. Methods 82 case of Peptic Ulcer bleeding patients were randomly divided into observation group and control group, 41 cases in each group. The observation group received endoscopic injection of norepinephrine and omeprazole combined treatment, and the control group received treatment of reptilase combined with omeprazole. Results The total effective rate of observation group was significantly superior to that of control group, and the difference was statistically significant(P < 0.05); Two groups of patients, 24 h, 48 h and 72 h after the treatment, the pH value on an empty stomach gastric juice were gradually elevated,there were statistically significant difference between before and after the treatment(P < 0.05), and the observation group was obviously better than the control group(P<0.05);Observation group of patients stop bleeding time, transfusion time, length of hospital stay were significantly lower than the control group(P<0.05), blood transfusion and hospitalization cost were decreased significantly(P<0.05), and incidence of bleeding again significantly was significantly lower than the control group(P < 0.05). In the two groups were not seen obvious adverse reactions. Conclusion Endoscopic injection of norepinephrine combined with omeprazole in patients with Peptic Ulcer bleeding is effective, Safe and reliable, it is worthy to be popularized.
