CAJ | 학술논문

通过硝基-L-精氨酸与3-甲基喹啉-8-磺酰氯缩合，再与（2R，4R）-4-甲基-2-哌啶甲酸乙酯缩合，经过酯水解，氢化，精制共五步反应，高收率地合成了抗血栓药物阿加曲班，该合成方法操作简单，工艺稳定，产品纯度较好，适合工业化生产。
통과초기-L-정안산여3-갑기규람-8-광선록축합，재여（2R，4R）-4-갑기-2-고정갑산을지축합，경과지수해，경화，정제공오보반응，고수솔지합성료항혈전약물아가곡반，해합성방법조작간단，공예은정，산품순도교호，괄합공업화생산。
Argatroban,an antithrombotic drug,was synthesized in high yield through a five-step route including condensation reaction of N-nitro-L-arginine and quinolinesulfonyl chloride,condensing with piperidine carboxylate,hydrolysis of esters, hydrogenation and purification.This method was considered to obtain highly pure products by simple operation and stable technique,which was suitable for industrialization.