CAJ | 학술논문

目的：探讨无功能性阑尾神经内分泌肿瘤的临床病理特点，免疫表型及预后。方法回顾性分析13例无功能性阑尾神经内分泌肿瘤的临床病理资料，对肿瘤进行光镜观察，并做免疫组化。结果无功能性阑尾神经内分泌肿瘤可分为4个临床病理分级，其病理学特点，生物学行为及预后均有不同。本组病例中无功能性阑尾神经内分泌肿瘤G18例，G23例，G3或神经内分泌癌2例，免疫组化检查AE1/AE3阳性3例， Syn阳性11例，CgA阳性10例。随访期内三个级别5年生存率分别为100%，100%，51%。结论无功能性阑尾神经内分泌肿瘤病理分级及临床分期与预后密切相关，对其治疗有指导作用，免疫组化合理应用可提高神经内分泌肿瘤的诊断率，减少临床误诊，避免过度治疗。
목적：탐토무공능성란미신경내분비종류적림상병리특점，면역표형급예후。방법회고성분석13례무공능성란미신경내분비종류적림상병리자료，대종류진행광경관찰，병주면역조화。결과무공능성란미신경내분비종류가분위4개림상병리분급，기병이학특점，생물학행위급예후균유불동。본조병례중무공능성란미신경내분비종류G18례，G23례，G3혹신경내분비암2례，면역조화검사AE1/AE3양성3례， Syn양성11례，CgA양성10례。수방기내삼개급별5년생존솔분별위100%，100%，51%。결론무공능성란미신경내분비종류병리분급급림상분기여예후밀절상관，대기치료유지도작용，면역조화합리응용가제고신경내분비종류적진단솔，감소림상오진，피면과도치료。
Objective To investigate the clinical and pathological characteristics of immune phenotype and prognosis of the non-functional appendix neuroendocrine tumor.Methods The clinical pathological data of 13 cases with no functional neuroendocrine tumor of the appendix were retrospectively analyzed, then the changes of tumor was observed, and immunohistochemistry were done. Results No functional appendix neuroendocrine tumors could be divided into four clinical pathologic stage, which pathological features, biological behavior and prognosis were different. Incidence of non-functional appendix neuroendocrine tumor G1 were 8 cases, G2 were 3 cases, G3 or neuroendocrine carcinoma were 2 cases, immunohistochemical examination showed that, AE1 / AE3 positive were 3 cases, the Syn positive were 11 cases, CgA positive were 10 cases. 5 survival rates in three level during follow-up period were 100%, 100%, 51% respectively.ConclusionNon-functional appendix neuroendocrine tumor pathological grading and clinical staging is closely related to the prognosis, and has guidance for treatment, reasonable application of immunohistochemical can improve the diagnosis rate of neuroendocrine tumor, reduce the clinical misdiagnosis, and avoid excessive treatment.