CAJ | 학술논문

目前普遍观点认为，肿瘤产生的本质是细胞增殖的调节失控，而细胞的增殖要通过细胞周期来调控。细胞周期调控激酶复合物[cyclin dependent kinase（CDK）/Cyclin]活性的异常是导致细胞周期失控的根本原因。抑制CDK/Cyclin激酶的活性成为有效治疗肿瘤的策略之一。因此，针对CDK/Cyclin激酶抑制剂的研究是当前抗肿瘤药物开发的热点之一。本文对近年来CDK/cyclin抑制剂的种类及目前其在临床应用中出现的问题进行概述。
목전보편관점인위，종류산생적본질시세포증식적조절실공，이세포적증식요통과세포주기래조공。세포주기조공격매복합물[cyclin dependent kinase（CDK）/Cyclin]활성적이상시도치세포주기실공적근본원인。억제CDK/Cyclin격매적활성성위유효치료종류적책략지일。인차，침대CDK/Cyclin격매억제제적연구시당전항종류약물개발적열점지일。본문대근년래CDK/cyclin억제제적충류급목전기재림상응용중출현적문제진행개술。
As normally accepted, the cell proliferation is regulated through cell cycle and the occurrence of tumor may lie in deregulation of cell cycle, directly resulted from the abnormal of the complex of cyclin dependent kinase(CDK).It has become one of the most effective strategies to inhibit the activity of the complex for dealing with tumors.Thus,the study on CDK/Cylclin complex inhibitors is one of hot focuses in antitumor drug discovery.This thesis mainly discusses the types of CDK/Cyclin inhibitors and their clinical issues.