CAJ | 학술논문

目的：探讨2型糖尿病(T2DM)患者尿酸结石形成的相关因素及机制。方法选择T2DM合并尿酸结石患者50例纳入观察组，随机选取同期诊治的未合并尿酸结石的T2DM患者50例纳入对照组，比较两组患者临床资料及生化指标的差异。结果观察组与对照组患者在年龄、性别、SBP、DBP、TC、FBG、2hPBG、HbA1C比较差异无统计学意义（P＞0.05），而两组患者在BMI、尿pH值、HOMA-IR、SUA、TUA方面比较差异有统计学意义（P＜0.05），多因素Logistic回归分析显示尿pH值、HOMA-IR是2型糖尿病患者尿酸结石形成的独立危险因素（P＜0.05）。结论高尿酸血症、高尿酸排泄、胰岛素抵抗、超重或肥胖、高甘油三酯血症在2型糖尿病患者尿酸结石形成中具有重要作用，其中尿pH值、HOMA-IR是2型糖尿病患者尿酸结石形成的独立危险因素。
목적：탐토2형당뇨병(T2DM)환자뇨산결석형성적상관인소급궤제。방법선택T2DM합병뇨산결석환자50례납입관찰조，수궤선취동기진치적미합병뇨산결석적T2DM환자50례납입대조조，비교량조환자림상자료급생화지표적차이。결과관찰조여대조조환자재년령、성별、SBP、DBP、TC、FBG、2hPBG、HbA1C비교차이무통계학의의（P＞0.05），이량조환자재BMI、뇨pH치、HOMA-IR、SUA、TUA방면비교차이유통계학의의（P＜0.05），다인소Logistic회귀분석현시뇨pH치、HOMA-IR시2형당뇨병환자뇨산결석형성적독립위험인소（P＜0.05）。결론고뇨산혈증、고뇨산배설、이도소저항、초중혹비반、고감유삼지혈증재2형당뇨병환자뇨산결석형성중구유중요작용，기중뇨pH치、HOMA-IR시2형당뇨병환자뇨산결석형성적독립위험인소。
ObjectiveTo investigate the factors and mechanisms in forming uric acid stones in patients with type 2 diabetes(T2DM).Methods 50 T2DM patients with uric acid stones were included into the observation group, and 50 T2DM patients without uric acid stones were randomly selected as the control group,the clinical and biochemical indicators were compared in the two groups.ResultsThere were no significant difference in observation group and control group in age,sex,SBP,DBP,TC,FBG,2hPBG and HbAlC(P>0.05),and there were of statistical difference significance in BMI,urinary pH,HOMA-IR,SUA,TUA in the two gruop(P<0.05),and theLogistic regression analysis showed the urinary pH,HOMA-IR,SUA were independent risk factors in uric acid stone formation in T2DM(P<0.05). Conclusion Hyperuricemia and high uric acid excretion,insulin resistance, overweight or obese, hypertriglyceridemia is play an important role in type 2 diabetes in uric acid stone formation,and the urinary pH,HOMA-IR,SUA were independent risk factors in uric acid stone formation in T2DM.