中国医药科学
中國醫藥科學
중국의약과학
CHINA MEDICINE AND PHARMACY
2014年
13期
9-12
,共4页
糖尿病%院内感染%多重耐药%易感因素
糖尿病%院內感染%多重耐藥%易感因素
당뇨병%원내감염%다중내약%역감인소
Diabetes%Hospital-acquired infection%Multiple drug-resistance%Predisposing factors
目的：探讨糖尿病患者院内多重耐药菌感染，为临床防治提供科学依据。方法选取惠州市中心人民医院2008年1月～2012年12月糖尿病患者发生院内感染的264例进行回顾性分析，以符合多重耐药感染的120例作为病例组，非多重耐药感染的144例作为对照组,所有病例均记录以下项目：一般情况、糖尿病病程、基础疾病、糖化血红蛋白、空腹血糖、餐后2h血糖、并发症、侵入性操作、免疫功能、抗生素的使用、感染后的预后。全部数据输入电脑,采用统计软件SPSS17.0进行汇总分析。结果5年来糖尿病患者院内感染、院内多重耐药菌的发病率逐年上升，以多重耐药感染上升的速度最快。以呼吸道感染最多，最常见的病原菌为革兰阴性菌（54.8%，136/248）。年龄、住院时间、ICU病房、空腹血糖、餐后2h血糖、糖化血红蛋白、昏迷、感染前30d使用抗生素、联用抗生素是多重耐药感染的易感因素。感染后30d内的死亡率高于对照组（P＜0.05）。结论糖尿病患者院内多重耐药菌的感染十分严重，与多种因素有关，预后不良，应针对易感因素采取综合性的防治措施。
目的：探討糖尿病患者院內多重耐藥菌感染，為臨床防治提供科學依據。方法選取惠州市中心人民醫院2008年1月～2012年12月糖尿病患者髮生院內感染的264例進行迴顧性分析，以符閤多重耐藥感染的120例作為病例組，非多重耐藥感染的144例作為對照組,所有病例均記錄以下項目：一般情況、糖尿病病程、基礎疾病、糖化血紅蛋白、空腹血糖、餐後2h血糖、併髮癥、侵入性操作、免疫功能、抗生素的使用、感染後的預後。全部數據輸入電腦,採用統計軟件SPSS17.0進行彙總分析。結果5年來糖尿病患者院內感染、院內多重耐藥菌的髮病率逐年上升，以多重耐藥感染上升的速度最快。以呼吸道感染最多，最常見的病原菌為革蘭陰性菌（54.8%，136/248）。年齡、住院時間、ICU病房、空腹血糖、餐後2h血糖、糖化血紅蛋白、昏迷、感染前30d使用抗生素、聯用抗生素是多重耐藥感染的易感因素。感染後30d內的死亡率高于對照組（P＜0.05）。結論糖尿病患者院內多重耐藥菌的感染十分嚴重，與多種因素有關，預後不良，應針對易感因素採取綜閤性的防治措施。
목적：탐토당뇨병환자원내다중내약균감염，위림상방치제공과학의거。방법선취혜주시중심인민의원2008년1월～2012년12월당뇨병환자발생원내감염적264례진행회고성분석，이부합다중내약감염적120례작위병례조，비다중내약감염적144례작위대조조,소유병례균기록이하항목：일반정황、당뇨병병정、기출질병、당화혈홍단백、공복혈당、찬후2h혈당、병발증、침입성조작、면역공능、항생소적사용、감염후적예후。전부수거수입전뇌,채용통계연건SPSS17.0진행회총분석。결과5년래당뇨병환자원내감염、원내다중내약균적발병솔축년상승，이다중내약감염상승적속도최쾌。이호흡도감염최다，최상견적병원균위혁란음성균（54.8%，136/248）。년령、주원시간、ICU병방、공복혈당、찬후2h혈당、당화혈홍단백、혼미、감염전30d사용항생소、련용항생소시다중내약감염적역감인소。감염후30d내적사망솔고우대조조（P＜0.05）。결론당뇨병환자원내다중내약균적감염십분엄중，여다충인소유관，예후불량，응침대역감인소채취종합성적방치조시。
Objective To explore hospital-acquired infections with multiple drug-resistant bacteria for patients with diabetes,and provide scientific evidence for clinical prevention and treatment. Methods264 patients with diabetes who had hospital-acquired infections in Huizhou Municipal Central Hospital from January 2008 to December 2012 were selected and analyzed retrospectively.120 patients who accorded with multiple drug-resistant infections were allocated to an experimental group,and 144 patients without multiple drug-resistant infections were allocated to a control group.Following items were recorded in all patients:general conditions,courses of diabetes,underlying diseases,glycosylated hemoglobin, fasting blood glucose,2-hour postprandial blood glucose,complications,invasive procedure,immune function, use of antibiotics,and prognosis of infections.All data were recorded in computers,and a pooled analysis was carried out via statistical software SPSS 17.0.ResultsIncidence of hospital-acquired infections with multiple drug-resistant bacteria for patients with diabetes increased year by year in recent five years.Incidence of multiple drug-resistant infections increased in the fastest fashion. The most commonly seen one was respiratory tract infection,and the most commonly seen pathogen was gram-negative bacteria(54.8%,136/248).Predisposing factors of multiple drug-resistant infections included age,hospitalization time,ICU wards,fasting blood sugar,2-hour postprandial blood sugar, glycosylated hemoglobin,coma,use of antibiotics 30 days before infections,and combined use of antibiotics. Mortality rate in 30 days after infections was higher than that in the control group(P<0.05). ConclusionHospital-acquired infections with multiple drug-resistant bacteria for patients with diabetes is severe, multifactor and poor in prognosis,and therefore comprehensive prevention measures should be taken on the basis of predisposing factors.
