中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2014年
15期
2285-2286,2287
,共3页
急性冠状动脉综合征%炎症介导素类%C反应蛋白质
急性冠狀動脈綜閤徵%炎癥介導素類%C反應蛋白質
급성관상동맥종합정%염증개도소류%C반응단백질
Acute coronary syndrome%Inflammation mediators%C-reactive protein
目的：探讨急性冠脉综合征（ ACS）患者血清中各项炎性指标的变化情况，以及发病前感染的发生情况。方法选取近三年确诊为ACS患者83例作为观察组，并选取同期住院的稳定型心绞痛患者或造影阴性的冠心病患者71例作为对照组。分别测定两组患者血清中CRP及IL-6的浓度水平。结果发病前观察组总感染率为41．0％，显著高于对照组的25．4％（χ2＝4．17，P＜0．05）；两组感染部位（包括上呼吸道感染、肺部感染、胆道感染、肠道感染、尿路感染、皮肤感染等）差异均无统计学意义（χ2＝1.96、1．27、0．84、0．92、0．92、0．88、0．88，均P＞0．05）；观察组CRP水平、IL-6含量分别为（7．52±1．62）mg/L、（247．55±62．17）ng/L，显著低于对照组的（2．76±1．01）mg/L、（99．25±30．63）ng/L（t＝21．44、18．28，均P＜0．05）。结论 ACS患者的急性起病与发病前急性感染可能存在相关性，而且ACS患者血清中的炎性指标明显升高，提示临床可以通过对患者炎性指标的检测进一步对ACS患者进行确诊。
目的：探討急性冠脈綜閤徵（ ACS）患者血清中各項炎性指標的變化情況，以及髮病前感染的髮生情況。方法選取近三年確診為ACS患者83例作為觀察組，併選取同期住院的穩定型心絞痛患者或造影陰性的冠心病患者71例作為對照組。分彆測定兩組患者血清中CRP及IL-6的濃度水平。結果髮病前觀察組總感染率為41．0％，顯著高于對照組的25．4％（χ2＝4．17，P＜0．05）；兩組感染部位（包括上呼吸道感染、肺部感染、膽道感染、腸道感染、尿路感染、皮膚感染等）差異均無統計學意義（χ2＝1.96、1．27、0．84、0．92、0．92、0．88、0．88，均P＞0．05）；觀察組CRP水平、IL-6含量分彆為（7．52±1．62）mg/L、（247．55±62．17）ng/L，顯著低于對照組的（2．76±1．01）mg/L、（99．25±30．63）ng/L（t＝21．44、18．28，均P＜0．05）。結論 ACS患者的急性起病與髮病前急性感染可能存在相關性，而且ACS患者血清中的炎性指標明顯升高，提示臨床可以通過對患者炎性指標的檢測進一步對ACS患者進行確診。
목적：탐토급성관맥종합정（ ACS）환자혈청중각항염성지표적변화정황，이급발병전감염적발생정황。방법선취근삼년학진위ACS환자83례작위관찰조，병선취동기주원적은정형심교통환자혹조영음성적관심병환자71례작위대조조。분별측정량조환자혈청중CRP급IL-6적농도수평。결과발병전관찰조총감염솔위41．0％，현저고우대조조적25．4％（χ2＝4．17，P＜0．05）；량조감염부위（포괄상호흡도감염、폐부감염、담도감염、장도감염、뇨로감염、피부감염등）차이균무통계학의의（χ2＝1.96、1．27、0．84、0．92、0．92、0．88、0．88，균P＞0．05）；관찰조CRP수평、IL-6함량분별위（7．52±1．62）mg/L、（247．55±62．17）ng/L，현저저우대조조적（2．76±1．01）mg/L、（99．25±30．63）ng/L（t＝21．44、18．28，균P＜0．05）。결론 ACS환자적급성기병여발병전급성감염가능존재상관성，이차ACS환자혈청중적염성지표명현승고，제시림상가이통과대환자염성지표적검측진일보대ACS환자진행학진。
Objective To explore the changes of serum inflammatory markers in patients with acute coronary syndrome(ACS),as well as the incidence of infection before the onset of the disease .Methods 83 patients with ACS were selected as the observation group ,and at the corresponding period of hospitalization ,71 patients with stable angi-na or coronary angiography negative were selected as the control group .The serum levels of C-reactive protein(CRP), interleukin-6(IL-6) were measured.Results Before the onset of the disease,the total infection rate of the observa-tion group was 41.0%,which was significantly higher than 25.4%of the control group,the difference was statistically significant(χ2 =4.17,P<0.05).The types of infections including upper respiratory infections ,lung infections,biliary tract infections,intestinal infections,urinary tract infections,skin infections between the two groups had no statistical differences(χ2 =1.96,1.27,0.84,0.92,0.92,0.88,0.88,all P>0.05).The CRP,IL-6 levels of the observation group were (7.52 ±1.62)mg/L,(247.55 ±62.17)ng/L,respectively,which were significantly lower than [(2.76 ± 1.01)mg/L,(99.25 ±30.63)ng/L]of the control group(t=21.44,18.28,all P<0.05).Conclusion ACS pa-tients with acute onset prior to the onset of acute infection may be correlated ,and serum inflammatory markers in ACS patients were significantly increased ,suggesting that through the clinical detection of inflammatory markers in patients with ACS will help for further diagnosis .
