CAJ | 학술논문

目的：探讨造血干细胞移植（HSCT ）治疗恶性血液病的疗效和并发症。方法：对13例恶性血液病患者施行造血干细胞移植（HSCT），其中自体HSCT（auto-HSCT）9例，异基因HSCT（allo-HSCT）4例。结果：所有患者均成功造血重建。auto-HSCT和allo-HSCT后中性粒细胞恢复≥0．5×109/L ，中位时间为16（9～29）d ，PLT 恢复≥20×109/L ，中位时间为62（12～298）d；发生急性、慢性移植物抗宿主病分别为4、3例；auto-HSCT 复发2例，死亡1例，allo-HSCT死亡1例。结论：HSCT可以延长生存期，提高生活质量，是治疗恶性血液病的有效方法。
목적：탐토조혈간세포이식（HSCT ）치료악성혈액병적료효화병발증。방법：대13례악성혈액병환자시행조혈간세포이식（HSCT），기중자체HSCT（auto-HSCT）9례，이기인HSCT（allo-HSCT）4례。결과：소유환자균성공조혈중건。auto-HSCT화allo-HSCT후중성립세포회복≥0．5×109/L ，중위시간위16（9～29）d ，PLT 회복≥20×109/L ，중위시간위62（12～298）d；발생급성、만성이식물항숙주병분별위4、3례；auto-HSCT 복발2례，사망1례，allo-HSCT사망1례。결론：HSCT가이연장생존기，제고생활질량，시치료악성혈액병적유효방법。
Objective :To investigate the clinical efficacy and complication of hematopoietic stem cell transplantation (HSCT) in 13 patients with malignant hematological disease .Methods :Thirteen patients with malignant hematological disease received HSCT ,including 9 cases of auto-HSCT ,4 cases of allo-HSCT .Results:All the patients had rapid he-mopoietic reconstitution .After auto-HSCT and allo-HSCT ,the time when the absolute neutrophil counts (ANC) were more than 0 .5 × 109/L were 9 and 29 days separately ,times of platelet count more than 20 × 109/L were 12 and 298 days separately ;acute and chronic graft-versus-host disease (GVHD) was observed in 4 and 3 cases separately ;2 cases relapsed and 1 case died in auto-HSCT group;1 case died in allo-HSCT group .Conclusion:HSCT has a good efficacy in the treatment of malignant hematological disease .It is suggested that the patients can get a obvious survival benefit from HSCT .