CAJ | 학술논문

目的：探讨依达拉奉联合七叶皂苷钠治疗急性脑出血的临床研究。方法将60例急性脑出血患者按数字表法随机分为对照组和观察组，每组各30例。对照组采用常规的内科治疗，观察组在对照组基础上分别给予依达拉奉和七叶皂苷钠静脉滴注。于治疗后14 d、28 d进行神经功能恢复情况，病灶体积，临床疗效评定。结果与对照组相比治疗后14 d、28 d，观察组NIHSS评分明显低于对照组义（ t＝2．136， t＝4.117，P＜0．05，P＜0．01）。治疗后14 d，血肿、水肿差异均无统计学意义（t＝1．395，t＝0．737，均P＞0．05）；治疗后28 d，血肿、水肿差异均有统计学意义（t＝3．140，t＝2．367，P＜0．01，P＜0．05）。两组总有效率差异有统计学意义（χ2＝6．650，P＜0．01）。结论依达拉奉联合七叶皂苷钠治疗脑出血可显著改善患者的神经功能缺损、血肿吸收、临床疗效，安全可靠。
목적：탐토의체랍봉연합칠협조감납치료급성뇌출혈적림상연구。방법장60례급성뇌출혈환자안수자표법수궤분위대조조화관찰조，매조각30례。대조조채용상규적내과치료，관찰조재대조조기출상분별급여의체랍봉화칠협조감납정맥적주。우치료후14 d、28 d진행신경공능회복정황，병조체적，림상료효평정。결과여대조조상비치료후14 d、28 d，관찰조NIHSS평분명현저우대조조의（ t＝2．136， t＝4.117，P＜0．05，P＜0．01）。치료후14 d，혈종、수종차이균무통계학의의（t＝1．395，t＝0．737，균P＞0．05）；치료후28 d，혈종、수종차이균유통계학의의（t＝3．140，t＝2．367，P＜0．01，P＜0．05）。량조총유효솔차이유통계학의의（χ2＝6．650，P＜0．01）。결론의체랍봉연합칠협조감납치료뇌출혈가현저개선환자적신경공능결손、혈종흡수、림상료효，안전가고。
Objective To investigate the clinical effect of edoravone combined with escin monosodium on the treatment of acute cerebral hemorrhage .Methods 60 patients suffered from acute cerebral hemorrhage were randomly divided into control group and observation group .Each group had 30 patients.The control group was conventionally treated by the internal medicine .On the basis of the research on the control group ,the observation group were treated by edoravone combined with escin monosodium intravenous drip .After the treatment of 14 days,28 days,the recovery of neural function,focus volume,clinical effect were evaluated.Results Comared with the control group,after the treatment of 14 days,28 days,NIHSS score was obviously lower than that of the control group ,the difference was sig-nificant (t=2.136,t=4.117,P<0.05,P<0.01).After the treatment of 14 days,hematoma and edema of the differences were not statistically significant (t=1.395,t=0.737,all P>0.05).After the treatment of 28 days,hema-toma and edema of the differences were statistically significant (t=3.140,t=2.367,P<0.01,P<0.05).The com-parison of the clinic effect of the two groups ,the total effect was statistically significant (χ2 =6.650,P <0.01). Conclusion Edaravone combined with escin monosodium on the treatment of cerebral hemorrhage can significantly improve neurologic impairment and cerebral hematoma .Clinical effect is definite and safe .