CAJ | 학술논문

目的：探讨参附注射液联合化疗治疗小细胞肺癌的临床疗效。方法100例小细胞肺癌患者采用数字表法均分为对照组与观察组，各为50例。对照组仅仅给予吉西他滨＋卡铂方案进行治疗，观察组在此基础上给予参附注射液60 mL，每天1次，连续使用10 d。两组1个疗程均为3周。比较两组疗效、治疗前后淋巴细胞亚群变化、术后并发症发生率、生活质量及肺功能。结果对照组临床总有效率为54．0％，明显低于观察组的86．0％（χ2＝8．36，P＜0．05）；对照组、观察组治疗前后淋巴细胞亚群的变化比较，差异均有统计学意义（t1＝5．36、5．12、4．68、5．68、4．78，t2＝5．28、5．13、5．68、4．12、4．66，均P＜0．05），且观察组治疗后较对照组治疗后差异有统计学意义（t＝5．22、5．73、4．56、5．03、4．85，均P＜0．05）；对照组术后并发症的发生率为16．0％，与观察组（14．0％）差异无统计学意义（χ2＝2．13，P＞0．05）；两组SGQR评分差异均有统计学意义（t＝4．29、5．34、4．93、6．22，均P＜0．05）；两组肺功能指标（FEV1、FEV1％、FVC及6 MWD）差异均有统计学意义（t＝4．19、5．23、4．52、4．39，均P＜0．05）。结论参附注射液联合化疗治疗小细胞肺癌，疗效显著，明显改善了患者的生活质量及肺功能，应在临床上加以推广并应用。
목적：탐토삼부주사액연합화료치료소세포폐암적림상료효。방법100례소세포폐암환자채용수자표법균분위대조조여관찰조，각위50례。대조조부부급여길서타빈＋잡박방안진행치료，관찰조재차기출상급여삼부주사액60 mL，매천1차，련속사용10 d。량조1개료정균위3주。비교량조료효、치료전후림파세포아군변화、술후병발증발생솔、생활질량급폐공능。결과대조조림상총유효솔위54．0％，명현저우관찰조적86．0％（χ2＝8．36，P＜0．05）；대조조、관찰조치료전후림파세포아군적변화비교，차이균유통계학의의（t1＝5．36、5．12、4．68、5．68、4．78，t2＝5．28、5．13、5．68、4．12、4．66，균P＜0．05），차관찰조치료후교대조조치료후차이유통계학의의（t＝5．22、5．73、4．56、5．03、4．85，균P＜0．05）；대조조술후병발증적발생솔위16．0％，여관찰조（14．0％）차이무통계학의의（χ2＝2．13，P＞0．05）；량조SGQR평분차이균유통계학의의（t＝4．29、5．34、4．93、6．22，균P＜0．05）；량조폐공능지표（FEV1、FEV1％、FVC급6 MWD）차이균유통계학의의（t＝4．19、5．23、4．52、4．39，균P＜0．05）。결론삼부주사액연합화료치료소세포폐암，료효현저，명현개선료환자적생활질량급폐공능，응재림상상가이추엄병응용。
Objective To investigate the clinical efficacy of shenfu injection combined with chemotherapy in the treatment of small cell lung cancer .Methods 100 cases of patients with small cell lung cancer were randomly di-vided into control group and observation group using the number table ,each group was 50 cases.The control group was given only gemcitabine +carboplatin treatment,and the observation group was given 60ml shenfu injection twice per day on the basis of the control group ,and it continued 10d.Two groups of a course of treatment was three weeks . Changes in lymphocyte subsets , the incidence of postoperative complications , quality of life and lung function were compared before and after treatment .Results The clinical total effective rate of control group was 54.0%,which was significantly lower than that of the observation group (86.0%),the difference existed a statistical significant difference (χ2 =8.36,P<0.05).Changes in lymphocyte subsets before and after treatment between the control group and the observation group,the differences were statistically significant (t1=5.36,5.12,4.68,5.68,4.78,t2=5.28,5.13, 5.68,4.12,4.66,all P<0.05) after treatment,the observation group than the control group ,the difference was sta-tistically significant(t=5.22,5.73,4.56,5.03,4.85,all P<0.05);The rate of postoperative complications in the contro group was 16.0%,14.0%in the observation group ,the difference existed no statistical difference (χ2 =2.13, P>0.05).According to the SGQR scoring standads ,there was a statistical difference between the two groups ( t=4.29,5.34,4.93,6.22,all P<0.05).There was a statistical difference of pulmonary function (FEV1,FEV1%,FVC and 6MWD) between the two groups(t=4.19,5.23,4.52,4.39,all P<0.05).Conclusion Shenfu injection combined with chemotherapy is applied in the treatment of small cell lung cancer ,which has a significant effect ,it can obviously improve the patient′s quality of life and lung function ,and it should be promoted and applied in clinical practice .