CAJ | 학술논문

目的：探讨血清IL-1、IL-6和TGF-β1水平在膝骨性关节炎患者中的变化及临床意义。方法应用酶联免疫吸附法检测80例膝骨性关节炎患者血清IL-1、IL-6和TGF-β1水平，并以80例健康体检者作对照。结果膝骨性关节炎患者血清中IL-1和IL-6水平均高于对照组（t＝71.132、78．503，均P＜0.01），而TGF-β1水平则低于对照组（t＝36．165，P＜0．01）；随着病变程度加重，血清中IL-1和IL-6水平显著增加，而TGF-β1水平则显著降低；血清IL-1、IL-6水平与血清TGF-β1水平呈显著负相关（ r＝-0．633，r＝-0．615；均P＜0．05），IL-1与IL-6呈显著正相关（r＝0．730，P＜0．01）。结论膝骨性关节炎患者血清IL-1、IL-6和TGF-β1水平反映了病情轻重及关节损伤程度，对病情和预后判断有重要价值。
목적：탐토혈청IL-1、IL-6화TGF-β1수평재슬골성관절염환자중적변화급림상의의。방법응용매련면역흡부법검측80례슬골성관절염환자혈청IL-1、IL-6화TGF-β1수평，병이80례건강체검자작대조。결과슬골성관절염환자혈청중IL-1화IL-6수평균고우대조조（t＝71.132、78．503，균P＜0.01），이TGF-β1수평칙저우대조조（t＝36．165，P＜0．01）；수착병변정도가중，혈청중IL-1화IL-6수평현저증가，이TGF-β1수평칙현저강저；혈청IL-1、IL-6수평여혈청TGF-β1수평정현저부상관（ r＝-0．633，r＝-0．615；균P＜0．05），IL-1여IL-6정현저정상관（r＝0．730，P＜0．01）。결론슬골성관절염환자혈청IL-1、IL-6화TGF-β1수평반영료병정경중급관절손상정도，대병정화예후판단유중요개치。
Objective To explore the clinical significance of changes of serum IL-1,IL-6 and TGF-β1 in pa-tients with Knee osteoarthritis(KOA).Methods Serum IL-1,IL-6 and TGF-β1 levels were measured by ELISA in 100 patients with KOA and 100 health control .Results The KOA group serum IL-1 and IL-6 levels were higher than those of the healthy control group (t=71.132,t=78.503,all P<0.01),while the level of TGF-β1 was converse(t=36.165,P<0.01);The levels of serum IL-1 and IL-6 increased gradually with the increase of the severity ,while.the level of TGF-β1 was decreased;the serum level of TGF-β1 was negative correlation with the level of IL-6,IL-8 in patients with KOA(r=-0.633,r=-0.615,all P<0.05),the serum level of IL-1 was positive correlation with the level of IL-6(r=0.730,P<0.01).Conclusion The serum IL-6,IL-8 and TGF-β1 reflect situation of patients and extent of Joint injury ,which is close relationship between the clinical process of KOA and has significance value to evaluate the pathogenetic condition and prognosis .