CAJ | 학술논문

目的：探讨阿维A联合甲氨蝶呤治疗难治性泛发性脓疱型银屑病的疗效及安全性。方法169例难治性泛发性脓疱型银屑病患者，采用数字表法随机分为阿维A组、甲氨蝶呤组以及阿维A与甲氨蝶呤联合治疗组，观察不同治疗方法的临床疗效与安全性。结果联合治疗组的总有效率为96．55％，明显高于阿维A组的83．93％以及甲氨蝶呤组的80．00％（χ2＝5．210、7．603，均P＜0．05）。联合治疗组不良反应发生率为41．38％，显著高于阿维A组的21．43％（χ2＝5．251，P＜0．05）。结论阿维A联合甲氨蝶呤治疗难治性泛发性脓疱型银屑病的临床疗效显著，安全性好，值得在临床中推广应用。
목적：탐토아유A연합갑안접령치료난치성범발성농포형은설병적료효급안전성。방법169례난치성범발성농포형은설병환자，채용수자표법수궤분위아유A조、갑안접령조이급아유A여갑안접령연합치료조，관찰불동치료방법적림상료효여안전성。결과연합치료조적총유효솔위96．55％，명현고우아유A조적83．93％이급갑안접령조적80．00％（χ2＝5．210、7．603，균P＜0．05）。연합치료조불량반응발생솔위41．38％，현저고우아유A조적21．43％（χ2＝5．251，P＜0．05）。결론아유A연합갑안접령치료난치성범발성농포형은설병적림상료효현저，안전성호，치득재림상중추엄응용。
Objective To discuss the efficacy and security of the treatment of Etretin and Methotrexate on refractory generalized pustular psoriasis .Methods 169 patients with refractory generalized pustular psoriasis were se-lected and randomly divided into 3 groups by the random number table .The efficacy and security were observed . Results The total efficiency of the combination therapy group was 94.83%and it was obviously higher than that of the etretin group and methotrexate group (χ2 =5.210,7.603,all P<0.05).The incidence of adverse reactions of the combination therapy group was 41.38%and it was obviously higher than that of the etretin group (21.43%) (χ2 =5.251,P<0.05) and made no significant difference with the methotrexate group .Conclusion Etretin combined with methotrexate on refractory generalized pustular psoriasis has a significant efficacy and make no difference with methotrexate group on security and deserved promotion .