CAJ | 학술논문

目的：探讨连续性肾替代治疗（ CRRT）时机对重症急性胰腺炎（ SAP）患者疗效的影响。方法回顾性分析38例重症急性胰腺炎患者的临床资料，按开始CRRT时机分为两组，早期组（21例）为重症急性胰腺炎发病后48 h内行连续性肾替代治疗，晚期组（17例）为48 h以后行连续性肾替代治疗，比较两组APACHEⅡ评分、ICU住院时间、28 d病死率。结果与早期组比较，晚期组第1、2天时APACHEⅡ评分均明显升高（ t＝2．231、2．304，均P＜0．05）；与早期组比较，晚期组入院时、CRRT开始时APACHEⅡ评分差异均无统计学意义（均P＞0．05）；与早期组比较，晚期组ICU住院时间、28 d病死率均明显升高（ t＝2．156，χ2＝4.293，均P＜0．05）；两组入院时年龄、性别、APACHE Ⅱ评分等差异均无统计学意义（均P＞0．05）。结论早期行CRRT治疗，可以降低SAP患者病死率，减少住院时间。
목적：탐토련속성신체대치료（ CRRT）시궤대중증급성이선염（ SAP）환자료효적영향。방법회고성분석38례중증급성이선염환자적림상자료，안개시CRRT시궤분위량조，조기조（21례）위중증급성이선염발병후48 h내행련속성신체대치료，만기조（17례）위48 h이후행련속성신체대치료，비교량조APACHEⅡ평분、ICU주원시간、28 d병사솔。결과여조기조비교，만기조제1、2천시APACHEⅡ평분균명현승고（ t＝2．231、2．304，균P＜0．05）；여조기조비교，만기조입원시、CRRT개시시APACHEⅡ평분차이균무통계학의의（균P＞0．05）；여조기조비교，만기조ICU주원시간、28 d병사솔균명현승고（ t＝2．156，χ2＝4.293，균P＜0．05）；량조입원시년령、성별、APACHE Ⅱ평분등차이균무통계학의의（균P＞0．05）。결론조기행CRRT치료，가이강저SAP환자병사솔，감소주원시간。
Objective To explore the effects of continuous renal replacement thempy ( CRRT) on efficacy in severe acute pancreatitis ( SAP) patients based on different time .Methods A total of 38 SAP patients were divided into two groups randomly:early group(CRRT within 48h) for 21 patients and late group(CRRT after 48h)for 17 pa-tients.the APACHE II score,the length of stay ICU and the mortality of 28d were compared between the two groups . Results The APACHE Ⅱscore was significantly higher in late group than that in early group in day 1 and 2 ( t=2.231,2.304,both P<0.05);there is no significant differences between late group than that early group in APACHEⅡscore before treatment(P>0.05);the hospitalizing days and mortality were significantly higher in late group than that in early group(t=2.156,χ2 =4.293,both P<0.05);there was no significant differences between late group and early group in gender,age,APACHEⅡscore(all P>0.05).Conclusion Early CRRT can decrease both the hospi-talizing days and mortality in SAP patients .CRRT may provide more clinical benefits in the early phase (within 48h) of SAP.