CAJ | 학술논문

目的：探讨神经生长因子在急性面神经炎患者中的临床应用效果。方法回顾性分析我院收治的104例急性面神经炎患者的临床资料，根据治疗方法不同分为治疗组和对照组各52例，对照组给予常规治疗，治疗组在对照组基础上加用神经生长因子治疗，比较治疗后2组临床疗效以及治疗前后 H-B面神经功能分级评价和 Sunnybrook评分。结果治疗组总有效率92.31％，对照组80.77％，2组比较有显著性差异（P＜0.05）；2组治疗前 H-B面神经功能分级评价和 Sunnybrook评分比较无显著性差异（P＞0.05）；2组治疗后 H-B分级评分均低于治疗前，治疗14 d 组间比较差异有统计学意义（P＜0.05）；治疗组 Sunnybrook评分治疗后7 d和14 d均显著高于对照组（P＜0.05）。结论神经生长因子治疗急性面神经炎，明显改善患者预后，临床效果显著。
목적：탐토신경생장인자재급성면신경염환자중적림상응용효과。방법회고성분석아원수치적104례급성면신경염환자적림상자료，근거치료방법불동분위치료조화대조조각52례，대조조급여상규치료，치료조재대조조기출상가용신경생장인자치료，비교치료후2조림상료효이급치료전후 H-B면신경공능분급평개화 Sunnybrook평분。결과치료조총유효솔92.31％，대조조80.77％，2조비교유현저성차이（P＜0.05）；2조치료전 H-B면신경공능분급평개화 Sunnybrook평분비교무현저성차이（P＞0.05）；2조치료후 H-B분급평분균저우치료전，치료14 d 조간비교차이유통계학의의（P＜0.05）；치료조 Sunnybrook평분치료후7 d화14 d균현저고우대조조（P＜0.05）。결론신경생장인자치료급성면신경염，명현개선환자예후，림상효과현저。
Objective To investigate the clinical effectiveness of nerve growth factor in patients with acute facial paralysis. Methods The clinical data of 104 patients with acute facial paralysis admitted to our hospital was taken for retrospective analy-sis.According to the different treatment methods,they were divided into the treatment group and the control group,and 52 ca-ses in each group.The control group received conventional therapy,and the treatment group took nerve growth factor on the basis of the control group.After treatment,the clinical efficacy was compared,and facial nerve function HB and Sunnybrook grading score of the two groups before and after treatment were compared.Results The total efficiency rate of the treatment group was 92.31%,and the total efficiency rate of the control group was 80.77%,there was significant difference in the total effective rates between the two groups(P <0.05).Before treatment,there was no significant difference in HB facial nerve function grading and Sunnybrook scores(P> 0.05).After treatment,the HB grading score in the treatment group was lower than that of the control group,and the difference was significant after treatment for 14 days.The sunnybrook score after treat-ment for 7 days and 14 days were significantly higher than those of the control group(P<0.05).Conclusion Nerve growth factor in the treatment of acute facial paralysis can significantly improve patients'outcomes,and the clinical effect is significant.