CAJ | 학술논문

目的：观察自体骨髓干细胞移植治疗慢性脊髓损伤患者的临床疗效及安全性。方法选择2010-01-2012-07江西省人民医院神经内科收治的慢性脊髓损伤患者28例，骨髓干细胞动员后，采自体骨髓干细胞进行鞘内注射移植治疗，骨髓干细胞数量（1.0～10.0）×107，1次/周，共治疗2次。分别于移植前和移植后1、3、12个月采用美国脊髓损伤学会（ASIA2000）制订的评分标准和改良的 Barthel指数（MBI）评估疗效，并观察患者的不良反应。结果 MSCs移植1个月后，针刺痛觉评分、轻触觉评分、运动评分和 MBI评分与入院时比较均明显改善（均P＜0.05）；移植3、12个月后各项评分与入院时比较均有显著差异（均P＜0.01）。其中8例低热和3例低颅压性头痛，处理后症状完全消失。结论自体 MSCs 移植治疗SCI可改善患者的运动和感觉功能，提高日常生活能力，且不良反应轻微。
목적：관찰자체골수간세포이식치료만성척수손상환자적림상료효급안전성。방법선택2010-01-2012-07강서성인민의원신경내과수치적만성척수손상환자28례，골수간세포동원후，채자체골수간세포진행초내주사이식치료，골수간세포수량（1.0～10.0）×107，1차/주，공치료2차。분별우이식전화이식후1、3、12개월채용미국척수손상학회（ASIA2000）제정적평분표준화개량적 Barthel지수（MBI）평고료효，병관찰환자적불량반응。결과 MSCs이식1개월후，침자통각평분、경촉각평분、운동평분화 MBI평분여입원시비교균명현개선（균P＜0.05）；이식3、12개월후각항평분여입원시비교균유현저차이（균P＜0.01）。기중8례저열화3례저로압성두통，처리후증상완전소실。결론자체 MSCs 이식치료SCI가개선환자적운동화감각공능，제고일상생활능력，차불량반응경미。
Objective To observe the clinical efficacy and the safety of chronic spinal cord injury treated with autologous bone marrow mesenchymal stem cell transplantation.Methods From Jan.2010 to Jul.2012,28 patients with chronic spinal cord injury were admitted to Department of Neurology of Jiangxi People's Hospital.All patients signed the informed consent form.The treatment protocol was approved by the hospital's medical ethics committee.After patients were mobilized for treat-ment with bone marrow stem cell,the treatment by autologous bone marrow stem cells (MSCs)was carried out with the num-ber of estimated (1.0 ~ 10.0)×107 cells collected for intrathecal transplantation therapy once a week,and twice in total.The standard for evaluation in accordance with ASIA2000 and improved Barthel index (MBI)were complied with to assess the effi-cacy and adverse reactions of the patients before the transplantation,one month,three months and 1 2 months after the trans-plantation respectively.Results 28 patients were included in the final analysis with no shedding indicated all along.One month after MSCs transplantation,the assessment by the acupuncture algesthesia,light touch sensation,exercise and MBI indicated an obvious improvement compared to that when these patients were admitted(all P<0.05).The assessment scores for 3 months and 1 2 months after transplantation were still in a signifi-cant difference compared with their initial condition when they were admitted (all P<0.001).There were 8 cases with low fever and 3 cases with intracranial hypotension headache,howev-er,the symptoms totally eliminated after a proper treatment.Conclusion Autologous MSCs transplantation on SCI patients could improve their exercise function and sensory function and develop their ADL ability with mild adverse reactions.