中外医学研究
中外醫學研究
중외의학연구
CHINESE AND FOREIGN MEDICAL RESEARCH
2014年
21期
21-22,23
,共3页
阙凤连%万艳%肖文霞%饶湖英
闕鳳連%萬豔%肖文霞%饒湖英
궐봉련%만염%초문하%요호영
2型糖尿病%脑钠肽%超敏C反应蛋白%左心室功能
2型糖尿病%腦鈉肽%超敏C反應蛋白%左心室功能
2형당뇨병%뇌납태%초민C반응단백%좌심실공능
Type 2 diabetes mellitus%B-type natriuretic peptide%High-sensitivity C-reactive protein%Left cardiac function
目的：探讨2型糖尿病(T2DM)患者血浆B型脑纳肽(BNP)、超敏C反应蛋白(hs-CRP)、左室舒张末内径(LVEDD)和左室射血分数(EF)的变化及其临床意义。方法：选择经治T2DM患者30例，新诊断T2DM患者20例，糖尿病前期患者20例，设对照组20例。分别测定BNP和hs-CRP水平，以及心脏彩超测定LVEDD、EF。结果：各组BNP、hs-CRP、LVEED和EF水平与对照组比较差异均有统计学意义(均P<0.05)。多元逐步回归分析提示，T2DM患者的BNP、hs-CRP水平与EF呈负相关(r=-0.549、-0.234，均P<0.01)，与LVEDD呈正相关(r=0.412、0.342，均P<0.01)。结论：(1)T2DM患者的BNP、hs-CRP水平与左心功能有关。(2)通过检测BNP、hs-CRP水平可预测T2DM患者的左心室功能。(3)血浆BNP、hs-CRP水平可用于2型糖尿病左心功能衰竭的风险及预后评估。
目的：探討2型糖尿病(T2DM)患者血漿B型腦納肽(BNP)、超敏C反應蛋白(hs-CRP)、左室舒張末內徑(LVEDD)和左室射血分數(EF)的變化及其臨床意義。方法：選擇經治T2DM患者30例，新診斷T2DM患者20例，糖尿病前期患者20例，設對照組20例。分彆測定BNP和hs-CRP水平，以及心髒綵超測定LVEDD、EF。結果：各組BNP、hs-CRP、LVEED和EF水平與對照組比較差異均有統計學意義(均P<0.05)。多元逐步迴歸分析提示，T2DM患者的BNP、hs-CRP水平與EF呈負相關(r=-0.549、-0.234，均P<0.01)，與LVEDD呈正相關(r=0.412、0.342，均P<0.01)。結論：(1)T2DM患者的BNP、hs-CRP水平與左心功能有關。(2)通過檢測BNP、hs-CRP水平可預測T2DM患者的左心室功能。(3)血漿BNP、hs-CRP水平可用于2型糖尿病左心功能衰竭的風險及預後評估。
목적：탐토2형당뇨병(T2DM)환자혈장B형뇌납태(BNP)、초민C반응단백(hs-CRP)、좌실서장말내경(LVEDD)화좌실사혈분수(EF)적변화급기림상의의。방법：선택경치T2DM환자30례，신진단T2DM환자20례，당뇨병전기환자20례，설대조조20례。분별측정BNP화hs-CRP수평，이급심장채초측정LVEDD、EF。결과：각조BNP、hs-CRP、LVEED화EF수평여대조조비교차이균유통계학의의(균P<0.05)。다원축보회귀분석제시，T2DM환자적BNP、hs-CRP수평여EF정부상관(r=-0.549、-0.234，균P<0.01)，여LVEDD정정상관(r=0.412、0.342，균P<0.01)。결론：(1)T2DM환자적BNP、hs-CRP수평여좌심공능유관。(2)통과검측BNP、hs-CRP수평가예측T2DM환자적좌심실공능。(3)혈장BNP、hs-CRP수평가용우2형당뇨병좌심공능쇠갈적풍험급예후평고。
Objective:To analyze the relationship between the levels of B-type natriuretic peptide(BNP),High-sensitivity C-reactive protein(hs-CRP) and left cardiac function in patients with type 2 diabetes mellitus(T2DM).Method:20 new-diagnosed T2DM patients,30 treated T2DM patients, 20 IGT/IFG patients and 20 health subjects were divided into DM1,DM2,DM0 and control group respectively.The serum levels of BNP and hs-CRP were determined.Meanwhile Left ventricular end-diastolic diameter(LVEDD) and Left ventricular ejection fraction(EF) were done in all four groups.The relationship between the levels of BNP,hs-CRP and LVEED,EF were analyzed.Result:The levels of BNP,hs-CRP,LVEED and EF in study groups were higher than that in control group(P<0.05).Multiple linear regression analysis for BNP,hs-CRP,and EF showed that BNP,hs-CRP were negatively correlated with EF(r=-0.549,-0.234,P<0.01),otherwise were positively correlated with LVEED(r=0.412,0.342,P<0.01).Conclusion:The BNP and hs-CRP have a good correlation with the left cardiac function,which may be a good prediction of left ventricular function and be used to assess the risk and prognosis of left ventricular failure in patients with T2DM.
