中外医学研究
中外醫學研究
중외의학연구
CHINESE AND FOREIGN MEDICAL RESEARCH
2014年
21期
15-16
,共2页
缬沙坦%ADHF%心肌肌钙蛋白T%高敏C-反应蛋白
纈沙坦%ADHF%心肌肌鈣蛋白T%高敏C-反應蛋白
힐사탄%ADHF%심기기개단백T%고민C-반응단백
Valsartan%Acute decompensated heart failure%Serum troponin T%High sensitive C-reactive protein
目的：观察缬沙坦对急性失代偿性心脏衰竭(ADHF)患者的临床疗效以及对患者血液中心肌肌钙蛋白T(cTnT)和超敏C-反应蛋白(hs-CRP)含量的影响。方法：选取笔者所在医院收治的76例急性失代偿性心脏衰竭ICU患者，采用随机数字表法将其分为缬沙坦组和对照组，各38例。对照组患者接受常规基础治疗，缬沙坦组在对照组基础上加用缬沙坦治疗，观察并比较两组患者住院期间的病死率、心力衰竭恶化和重复情况、ICU住院时间、不良反应情况，同时检测两组患者cTnT、hs-CRP的变化。结果：缬沙坦组患者在ICU住院时间明显少于对照组，差异有统计学意义(P<0.05)。治疗前比较，两组患者血液内cTnT及hs-CRP含量水平均明显下降，差异有统计学意义(P<0.05)；且缬沙坦组低于对照组，差异有统计学意义(P<0.05)。结论：在常规基础治疗的同时加用缬沙坦，可明显降低ADHF患者心力衰竭的反复次数，缩短ADHF患者的住院时间，其药理作用机制有可能是缬沙坦可明显降低患者血清中cTnT和hs-CRP的水平。
目的：觀察纈沙坦對急性失代償性心髒衰竭(ADHF)患者的臨床療效以及對患者血液中心肌肌鈣蛋白T(cTnT)和超敏C-反應蛋白(hs-CRP)含量的影響。方法：選取筆者所在醫院收治的76例急性失代償性心髒衰竭ICU患者，採用隨機數字錶法將其分為纈沙坦組和對照組，各38例。對照組患者接受常規基礎治療，纈沙坦組在對照組基礎上加用纈沙坦治療，觀察併比較兩組患者住院期間的病死率、心力衰竭噁化和重複情況、ICU住院時間、不良反應情況，同時檢測兩組患者cTnT、hs-CRP的變化。結果：纈沙坦組患者在ICU住院時間明顯少于對照組，差異有統計學意義(P<0.05)。治療前比較，兩組患者血液內cTnT及hs-CRP含量水平均明顯下降，差異有統計學意義(P<0.05)；且纈沙坦組低于對照組，差異有統計學意義(P<0.05)。結論：在常規基礎治療的同時加用纈沙坦，可明顯降低ADHF患者心力衰竭的反複次數，縮短ADHF患者的住院時間，其藥理作用機製有可能是纈沙坦可明顯降低患者血清中cTnT和hs-CRP的水平。
목적：관찰힐사탄대급성실대상성심장쇠갈(ADHF)환자적림상료효이급대환자혈액중심기기개단백T(cTnT)화초민C-반응단백(hs-CRP)함량적영향。방법：선취필자소재의원수치적76례급성실대상성심장쇠갈ICU환자，채용수궤수자표법장기분위힐사탄조화대조조，각38례。대조조환자접수상규기출치료，힐사탄조재대조조기출상가용힐사탄치료，관찰병비교량조환자주원기간적병사솔、심력쇠갈악화화중복정황、ICU주원시간、불량반응정황，동시검측량조환자cTnT、hs-CRP적변화。결과：힐사탄조환자재ICU주원시간명현소우대조조，차이유통계학의의(P<0.05)。치료전비교，량조환자혈액내cTnT급hs-CRP함량수평균명현하강，차이유통계학의의(P<0.05)；차힐사탄조저우대조조，차이유통계학의의(P<0.05)。결론：재상규기출치료적동시가용힐사탄，가명현강저ADHF환자심력쇠갈적반복차수，축단ADHF환자적주원시간，기약리작용궤제유가능시힐사탄가명현강저환자혈청중cTnT화hs-CRP적수평。
Objective:To observe the effect of valsartan in acutedecompensated heart failure (ADHF) in patients with clinical efficacy as well as to the blood center in patients with cardiac troponin T(cTnT) and high sensitive C-reactive protein(hs-CRP) content influence.Method:76 case of patients with acute decompensated heart failure were treated in author’s hospital,were randomly divided into valsartan group and control group,38 cases in each. The control group received routine treatment,valsartan group was treated with valsartan in the treatment ofobservation period,and mortality,heart failuredeterioration rate and the number of iterations,ICU ward hospitalization,adverse reactions were compared between two groups of patients,and to detect changes in two groups of patients cTnT,hs-CRP.Result:Valsartan group patients in the ICU ward hospitalization time was less than that in the control group,the difference was statistically significant(P<0.05). Comparison of two groups of patients before treatment,blood cTnT and hs-CRP levels were significantly decreased,the difference was statistically significant(P<0.05);and valsartan group was lower than the control group,the difference was statistically significant(P<0.05).Conclusion:At the same time the routine treatment plus valsartan,repetition can significantly reduce heart failure in patients with ADHF,shorten the time ofhospitalization in patients with ADHF,its pharmacological mechanism may be valsartan can significantly reduce cTnT and CRP level in the serum of patients with.
