中外医学研究
中外醫學研究
중외의학연구
CHINESE AND FOREIGN MEDICAL RESEARCH
2014年
21期
11-12
,共2页
雷公藤多苷%泼尼松%原发性肾病综合征
雷公籐多苷%潑尼鬆%原髮性腎病綜閤徵
뢰공등다감%발니송%원발성신병종합정
Tripterygium glycosides%Prednisone%Primary nephritic syndrome
目的：探讨雷公藤多苷联合小剂量泼尼松治疗老年原发性肾病综合征的临床应用及疗效。方法：选取2011年2月-2013年5月笔者所在医院收治的老年原发性肾病综合征患者98例，随机将其分为对照组和观察组，各49例，其中对照组患者给予雷公藤多苷进行治疗，观察组给予雷公藤多苷联合小剂量泼尼松进行治疗，治疗前及治疗后第2、4、8、24周分别进行检查，观察24 h尿蛋白定量、血浆白蛋白(Alb)等指标变化情况及疗效。结果：统计结果显示，观察组中完全缓解18例，显著缓解23例，部分缓解5例，无改善3例，总缓解率为83.7%；对照组中完全缓解12例，显著缓解18例，部分缓解14例，无改善5例，总缓解率为61.2%，两组总缓解率比较差异有统计学意义(P<0.05)。蛋白尿、血浆白蛋白等观察指标两组治疗后较治疗前均有所改善，差异有统计学意义(P<0.05)。结论：雷公藤多苷联合小剂量泼尼松在治疗老年原发性肾病综合征中疗效显著，治疗有效率高，预后情况良好，值得在临床上进行推广和应用。
目的：探討雷公籐多苷聯閤小劑量潑尼鬆治療老年原髮性腎病綜閤徵的臨床應用及療效。方法：選取2011年2月-2013年5月筆者所在醫院收治的老年原髮性腎病綜閤徵患者98例，隨機將其分為對照組和觀察組，各49例，其中對照組患者給予雷公籐多苷進行治療，觀察組給予雷公籐多苷聯閤小劑量潑尼鬆進行治療，治療前及治療後第2、4、8、24週分彆進行檢查，觀察24 h尿蛋白定量、血漿白蛋白(Alb)等指標變化情況及療效。結果：統計結果顯示，觀察組中完全緩解18例，顯著緩解23例，部分緩解5例，無改善3例，總緩解率為83.7%；對照組中完全緩解12例，顯著緩解18例，部分緩解14例，無改善5例，總緩解率為61.2%，兩組總緩解率比較差異有統計學意義(P<0.05)。蛋白尿、血漿白蛋白等觀察指標兩組治療後較治療前均有所改善，差異有統計學意義(P<0.05)。結論：雷公籐多苷聯閤小劑量潑尼鬆在治療老年原髮性腎病綜閤徵中療效顯著，治療有效率高，預後情況良好，值得在臨床上進行推廣和應用。
목적：탐토뢰공등다감연합소제량발니송치료노년원발성신병종합정적림상응용급료효。방법：선취2011년2월-2013년5월필자소재의원수치적노년원발성신병종합정환자98례，수궤장기분위대조조화관찰조，각49례，기중대조조환자급여뢰공등다감진행치료，관찰조급여뢰공등다감연합소제량발니송진행치료，치료전급치료후제2、4、8、24주분별진행검사，관찰24 h뇨단백정량、혈장백단백(Alb)등지표변화정황급료효。결과：통계결과현시，관찰조중완전완해18례，현저완해23례，부분완해5례，무개선3례，총완해솔위83.7%；대조조중완전완해12례，현저완해18례，부분완해14례，무개선5례，총완해솔위61.2%，량조총완해솔비교차이유통계학의의(P<0.05)。단백뇨、혈장백단백등관찰지표량조치료후교치료전균유소개선，차이유통계학의의(P<0.05)。결론：뢰공등다감연합소제량발니송재치료노년원발성신병종합정중료효현저，치료유효솔고，예후정황량호，치득재림상상진행추엄화응용。
Objective:To investigate the clinical application and efficacy of Tripterygium Glycosides combined with low-dose Prednisone therapy in elderly primary nephritic syndrome.Method:98 patients were selected from February 2011 to May 2013 in our hospital for elderly patients with primary nephritic syndrome,according to the random principle they were divided into control group and the observation group,49 cases in each,the control group was treated with Tripterygium Glycosides treatment,the observation group was treated with Tripterygium Glycosides combined with low-dose Prednisone,the effect and the 24 h urinary protein,plasma albumin(Alb) and so on were observed before treatment and after treatment 2,4,8,24 weeks.Result:The statistical results show, the observation group of 18 cases of complete remission,significant remission in 23 cases,partial remission in 5 cases,no improvement in 3 cases,the total response rate was 83.7%.The control group of 12 cases of complete remission,significantly relieved in 18 cases,partial remission in 14 cases,no improvement in 5 cases,the total response rate was 61.2%.The total response rate in two groups was statistically significant(P<0.05).Urine protein,plasma albumin,observed the two groups after treatment than before treatment improved,the differences were statistically significant(P<0.05).Conclusion:Tripterygium Glycosides combined with low-dose Prednisone in the treatment of elderly patients with primary nephritic syndrome has a significant effect,the effective rate of the treatment is high, the prognosis is good,it is worthy of promotion and application in clinical practice.
