CAJ | 학술논문

目的：探讨糖皮质激素对鼻息肉组织中黏蛋白MUC4表达的影响。方法2009年12月至2011年12月在我院行鼻内镜手术患者85例，随机分为两组，对照组43例，治疗组42例。对照组术前未予处理，治疗组术前2周予辅舒良。免疫组织化学SP法检测鼻息肉黏膜组织中MUC4蛋白的表达情况。结果对照组鼻息肉组织中MUC4的阳性表达率为37.2%，而治疗组MUC4的阳性表达率为7.1%，两组间比较，差异有统计学意义（P＜0.05）。结论 MUC4基因在鼻息肉组织中存在表达，糖皮质激素可下调黏蛋白MUC4基因表达，这可能是它抑制鼻息肉黏液过度分泌的途径之一。
목적：탐토당피질격소대비식육조직중점단백MUC4표체적영향。방법2009년12월지2011년12월재아원행비내경수술환자85례，수궤분위량조，대조조43례，치료조42례。대조조술전미여처리，치료조술전2주여보서량。면역조직화학SP법검측비식육점막조직중MUC4단백적표체정황。결과대조조비식육조직중MUC4적양성표체솔위37.2%，이치료조MUC4적양성표체솔위7.1%，량조간비교，차이유통계학의의（P＜0.05）。결론 MUC4기인재비식육조직중존재표체，당피질격소가하조점단백MUC4기인표체，저가능시타억제비식육점액과도분비적도경지일。
Objective To investigate the effect of MUC4 expression on nasal polyp organization after local glucocorticoids application. Methods From Dec 2009 to Dec 2011, 85 cases of nasal polyp mucosa in our hospital were enrolled and divided into two groups, control group(n=43)and therapeutic group(n=42). No additional treatment was performed in control group, flixonase was applied 2 weeks before endoscopic surgery. MUC4 expression of nasal polyp mucosa tissues was detected by immunohistochemical SP method. Results The positive expression rate of MUC4 of nasal polyp was 37.2%in control group, but 7.1%in therapeutic group(P<0.05). Conclusion MUC4 genes expression existed in nasal polyps, and glucocorticoid can down-regulate the MUC4 gene expression, which could be one of the ways inhibit nasal mucus hypersecretion.