中国医药指南
中國醫藥指南
중국의약지남
CHINA MEDICINE GUIDE
2014年
21期
10-12
,共3页
前白蛋白%胆碱酯酶%总胆汁酸%肝炎%肝硬变
前白蛋白%膽堿酯酶%總膽汁痠%肝炎%肝硬變
전백단백%담감지매%총담즙산%간염%간경변
Prealbumin%Cholinesterase%Total bile acid%Hepatitis%Hepatic cirrhosis
目的:探讨病毒性肝病患者血清PA、CHE、TBA的变化及其在临床诊断分型中的意义。方法采用HITACHI-7080型全自动生化分析仪检测65例健康对照者和236例各临床型的病毒性肝病患者的血清PA、CHE、TBA,其分为急性肝炎、慢性肝炎、重型肝炎和肝硬变患者。同时检测白蛋白(ALB)、丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)、r-谷氨酸转肽酶(r-GT或GGT)、总胆红素(TBIL)。结果各组肝病患者的血清PA、CHE明显低于对照组,TBA水平(慢性轻度肝炎组除外)显著高于正常对照组(P<0.05)。慢性肝炎患者血清PA、CHE含量与慢性肝炎发展阶段性相一致,在慢性重度肝炎与肝硬变阶段达最低水平。结论检测血清PA、CHE、TBA三项指标对于病毒性肝病早期诊断、动态观察及预后评估具有一定的理论和临床价值。
目的:探討病毒性肝病患者血清PA、CHE、TBA的變化及其在臨床診斷分型中的意義。方法採用HITACHI-7080型全自動生化分析儀檢測65例健康對照者和236例各臨床型的病毒性肝病患者的血清PA、CHE、TBA,其分為急性肝炎、慢性肝炎、重型肝炎和肝硬變患者。同時檢測白蛋白(ALB)、丙氨痠轉氨酶(ALT)、天鼕氨痠轉氨酶(AST)、r-穀氨痠轉肽酶(r-GT或GGT)、總膽紅素(TBIL)。結果各組肝病患者的血清PA、CHE明顯低于對照組,TBA水平(慢性輕度肝炎組除外)顯著高于正常對照組(P<0.05)。慢性肝炎患者血清PA、CHE含量與慢性肝炎髮展階段性相一緻,在慢性重度肝炎與肝硬變階段達最低水平。結論檢測血清PA、CHE、TBA三項指標對于病毒性肝病早期診斷、動態觀察及預後評估具有一定的理論和臨床價值。
목적:탐토병독성간병환자혈청PA、CHE、TBA적변화급기재림상진단분형중적의의。방법채용HITACHI-7080형전자동생화분석의검측65례건강대조자화236례각림상형적병독성간병환자적혈청PA、CHE、TBA,기분위급성간염、만성간염、중형간염화간경변환자。동시검측백단백(ALB)、병안산전안매(ALT)、천동안산전안매(AST)、r-곡안산전태매(r-GT혹GGT)、총담홍소(TBIL)。결과각조간병환자적혈청PA、CHE명현저우대조조,TBA수평(만성경도간염조제외)현저고우정상대조조(P<0.05)。만성간염환자혈청PA、CHE함량여만성간염발전계단성상일치,재만성중도간염여간경변계단체최저수평。결론검측혈청PA、CHE、TBA삼항지표대우병독성간병조기진단、동태관찰급예후평고구유일정적이론화림상개치。
Objective To determine the role of prealbumin(PA), cholinesterase(CHE) and total bile acid (TBA)in diagnosing patients with viral liver disease. Methods Serum level of PA、CHE and TBA were measured by HITACHI-7080 automatic analyzer in 65 healthy controls and 236 patients with acute hepatitis, chronic hepatitis or hepatic cirrhosis. At the same time, ALB, ALT, AST, GGT and TBIL were measured. Results The result showed that the serum levels of PA, CHE of these patients were lower, while the levels of and TBA (excluding patients with light hepatitis)were higher significantly than that of healthy controls(P<0.05).The level of the serum PA,CHE in patients with chronic hepatitis was consistent with its development stages, which reached the lowest level at the severe stage of chronic hepatitis and hepatic cirrhosis. Conclusion The measurement of the concentration of serum PA, CHE, TBA is of some theoretic and clinical significance in the dynamic observation of liver fibrosis, the early diagnosis, therapy and the estimate of the prognosis.